Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 35 - 70 |
| Updated: | 3/28/2019 |
| Start Date: | July 1, 2017 |
| End Date: | April 30, 2021 |
As the leading cause of death, cardiovascular disease (CVD) accounts for about one-third of
U.S. mortality. Physical inactivity, one of the main CVD risk factors, causes 6% of coronary
heart disease worldwide. The American Heart Association has identified cardiovascular health
behaviors including smoking, obesity, diet, and aerobic exercise; however, resistance
exercise was not included due to the limited evidence of its efficacy. Comparatively, the
cardiovascular benefits of aerobic training have been well-documented whereas the independent
and additive benefits of resistance training on cardiovascular health have not been
established. Thus, this project is aimed to answer one of the most common questions about
exercise and health:"What type or combination of exercise is most effective for CVD
prevention?" This project will significantly contribute to developing more effective CVD
prevention approaches, advancing more comprehensive physical activity guidelines, and
providing important insights and novel opportunities for the future science of physical
activity and health.
U.S. mortality. Physical inactivity, one of the main CVD risk factors, causes 6% of coronary
heart disease worldwide. The American Heart Association has identified cardiovascular health
behaviors including smoking, obesity, diet, and aerobic exercise; however, resistance
exercise was not included due to the limited evidence of its efficacy. Comparatively, the
cardiovascular benefits of aerobic training have been well-documented whereas the independent
and additive benefits of resistance training on cardiovascular health have not been
established. Thus, this project is aimed to answer one of the most common questions about
exercise and health:"What type or combination of exercise is most effective for CVD
prevention?" This project will significantly contribute to developing more effective CVD
prevention approaches, advancing more comprehensive physical activity guidelines, and
providing important insights and novel opportunities for the future science of physical
activity and health.
Participants will be randomly assigned to aerobic exercise, resistance exercise, combined
aerobic and resistance exercise, or a no exercise control group for 1 year. Participants in
all four groups will receive healthy diet and lifestyle education sessions and will track
their daily steps, body weights, and food intake throughout the 1-year intervention. They
will also complete baseline, 6-month, and 12-month physical examinations, which will include
assessments of blood pressure, blood lipids, body composition, and aerobic and muscular
fitness.
aerobic and resistance exercise, or a no exercise control group for 1 year. Participants in
all four groups will receive healthy diet and lifestyle education sessions and will track
their daily steps, body weights, and food intake throughout the 1-year intervention. They
will also complete baseline, 6-month, and 12-month physical examinations, which will include
assessments of blood pressure, blood lipids, body composition, and aerobic and muscular
fitness.
Inclusion Criteria:
- Non-smoker
- Systolic/diastolic blood pressure of 120-139/80-89 mmHg (without taking any
anti-hypertensive medication)
- Overweight or obese: body mass index of 25-40 kg/m2; Asian 23-40 kg/m2
- Inactive: less than 150 min/week of exercise over the past 3 months
- Capable of performing the required exercise training
Exclusion Criteria:
- Unstable coronary heart disease or heart failure
- Uncontrolled arrhythmias or severe aortic stenosis
- Acute myocarditis, endocarditis, or pericarditis
- Cancer, requiring treatment in the past 5 years
- Autoimmune diseases, affecting the immune system
- Plans to be away/travel for greater than 4 weeks in the next year
- Pregnancy/anticipated pregnancy during the study
- Other medical condition that is life-threatening or can interfere with or be
aggravated by the exercise training
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