Effect of Changing Physiological Conditions on Myogenic Oscillations: Pilot Study
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/28/2018 |
| Start Date: | October 23, 2018 |
| End Date: | October 1, 2020 |
| Contact: | Pekka Talke, MD |
| Email: | pekka.talke@ucsf.edu |
| Phone: | 415 476 8963 |
A Pilot Study to Evaluate the Effect of Changing Physiological Conditions on the Amplitude and/or Frequency of Myogenic Oscillations
Spontaneous myogenic oscillations will be studied under general anesthesia using finger
photoplethysmography. This pilot study will explore potential physiological conditions that
will effect the amplitude and/or frequency of myogenic oscillations.
photoplethysmography. This pilot study will explore potential physiological conditions that
will effect the amplitude and/or frequency of myogenic oscillations.
This is a single center, nonrandomized, nonblinded, interventional clinical pilot research
study that plans to enroll 40 patients.
Study will be conducted while subjects are under general anesthesia.
Myogenic oscillations will be measured using finger photoplethysmography. Changes in the
amplitude and/or frequency of these oscillations will be analyzed in response to the
interventions. Arterial blood pressure will be recorded to verify the efficacy of the
interventions.
Six different interventions that will either lower or increase blood pressure will be applied
to the subjects. Each subject will receive 1 or 2 of the six interventions. Each of the 6
interventions will be applied to 8 subject.
The interventions that the subject will not be randomized. They will be determined by the
subjects blood pressure immediately before the intervention to guarantee that the blood
pressure manipulations are within a safe range.
Data will be analyzed offline using Matlab.
study that plans to enroll 40 patients.
Study will be conducted while subjects are under general anesthesia.
Myogenic oscillations will be measured using finger photoplethysmography. Changes in the
amplitude and/or frequency of these oscillations will be analyzed in response to the
interventions. Arterial blood pressure will be recorded to verify the efficacy of the
interventions.
Six different interventions that will either lower or increase blood pressure will be applied
to the subjects. Each subject will receive 1 or 2 of the six interventions. Each of the 6
interventions will be applied to 8 subject.
The interventions that the subject will not be randomized. They will be determined by the
subjects blood pressure immediately before the intervention to guarantee that the blood
pressure manipulations are within a safe range.
Data will be analyzed offline using Matlab.
Inclusion Criteria:
1. Over 18 yrs of age
2. Undergoing surgery in Moffitt-Long operating rooms
3. Receiving general anesthesia
4. Will have an intra-arterial catheter for clinical purposes
5. Able to consent in english
Exclusion Criteria:
1. Under 18 years of age
2. unable to provide informed consent
3. Pregnancy
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