Hereditary Colorectal and Associated Tumor Registry Study



Status:Recruiting
Conditions:Colorectal Cancer, Cancer, Other Indications
Therapuetic Areas:Oncology, Other
Healthy:No
Age Range:8 - 100
Updated:4/21/2016
Start Date:April 2012
End Date:December 2020
Contact:Randall E Brand, MD
Email:brandre@upmc.edu
Phone:412-623-3105

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Trial Summary
Trial Overview
Inclusion Criteria
After informed consent, participants will be asked to complete a medical/family history
questionnaire and provide a blood sample. Participants will also be asked for their
permission for study investigators to access medical records and/or recontact them for
updates to their medical and family histories. Data and biospecimens will be stored for
potential future research projects.


Inclusion Criteria:

- Identified gene mutation

- Personal history of colorectal cancer diagnosed ≤ 50

- Personal history of cancer with tumor studies suggestive of Lynch syndrome

- Personal history of multiple primary tumors associated with a hereditary cancer
syndrome (colorectal, uterus, stomach, ovary, small bowel, hepatobiliary tract,
transitional cell carcinoma of the renal pelvis/ureter, brain)

- Personal history of one of the above cancers and a family history of one or more of
the above cancers

- Personal or family history of diffuse gastric cancer

- From a known genetic predisposition family

- Personal history of > 10 colon adenomas (cumulative over a lifetime)

- Personal history of any number of hamartomatous polyps

- Personal history of multiple large (> 1cm) serrated polyps to right of sigmoid

Exclusion critera:

- Individuals under the age of 8

- Individuals who cannot travel to Pittsburgh for in-person enrollment

- Individuals who cannot provide informed consent
We found this trial at
1
site
University of Pittsburgh
4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
Phone: 412-623-3105
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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