Prophylactic Use of Filgrastim SD/01 in Patients With Hodgkin's Disease Receiving ABVD Chemotherapy

INCLUSION:

- Previously untreated Hodgkin's disease patients who are scheduled to receive standard
ABVD chemo.

- Histologically proven diagnosis of Hodgkin's disease of any type.

- Bidimensionally measurable disease.

- Signed informed consent.

- Age >/= 16 yrs.

- Adequate bone marrow reserve (ANC>1000/uL, Platelet >100,000/uL.

- LVEF>/=50% by MUGA scan or echocardiogram.

- Serum creatinine <2mg/dL; serum bilirubin<2mg/dL.

EXCLUSION:

- HIV positive.

- Pregnant women and those of child bearing age who are not using adequate
contraception.

- Prior chemotherapy.

- Severe pulmonary disease including COPD and asthma.

- History of prior sensitivity to E.coli derived products.