Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression

Status:	Completed
Conditions:	Orthopedic
Therapuetic Areas:	Orthopedics / Podiatry
Healthy:	No
Age Range:	18 - Any
Updated:	3/30/2013
Start Date:	March 2008
End Date:	October 2013
Contact:	Branko Kopjar, MD, MPH
Email:	branko.kopjar@nor-consult.com
Phone:	+1 206 949-4728

Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression. Quality of Life and Cost-effectiveness Outcomes

The aim of this trial is to evaluate the differences in pain relief, neurological function,
quality of life and survival in patients with metastatic epidural spinal cord compression
(MESCC) who are managed with a combination of surgery and radiotherapy versus radiotherapy
alone.

Further we shall evaluate cost-effectiveness of the two treatment approaches.

Inclusion Criteria:

- Single symptomatic metastatic epidural spinal compression at any level confirmed by
MRI

- Age 18 and more

- Able and willing to give written informed consent to participate in the study

- Able to read and write English on an elementary level

Exclusion Criteria:

- Multiple symptomatic spinal metastases

- Radiosensitive tumors

- Radioresistant tumors

- Primary cancer site in CNS or spine

- Poor life expectancy (< 3 months)

- Patients with a tumor that has compressed only the cauda equina or spinal roots

- Has a recent history of substance abuse

- Is a prisoner

- Currently involved in another study

- has a disease or condition that would preclude accurate evaluation

We found this trial at

sites

University of Texas Hospital/ MD Anderson Cancer Center

Houston, Texas 77030

from

Houston, TX