The Effect of Bariatric Surgery on Spermatogenesis
| Status: | Not yet recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 11/7/2018 |
| Start Date: | November 1, 2018 |
| End Date: | December 31, 2020 |
| Contact: | Scott Lundy |
| Email: | lundys@ccf.org |
| Phone: | 2163796134 |
Little is known about the effects of weight loss surgery on male reproductive health. This
study will investigate the effect of bariatric surgery on male infertility by evaluating
sexual health, blood hormone levels, and semen parameters before and after roux-en-y
bariatric surgery.
study will investigate the effect of bariatric surgery on male infertility by evaluating
sexual health, blood hormone levels, and semen parameters before and after roux-en-y
bariatric surgery.
Obesity is a worldwide epidemic that has numerous health consequences including male
infertility. Prior studies have shown a variety of health benefits with bariatric surgery,
including an improvement/resolution in diabetes and a significant improvement in serum
testosterone levels. Based upon preliminary data from the literature, the investigators
hypothesize that bariatric surgery is associated with a transient decrease followed by a
robust long-term improvement in semen parameters including DNA fragmentation and oxidative
stress. To test this hypothesis, the investigators propose a prospective observational study
examining changes in hormone and semen parameters over the 12 months following Roux-en-Y
gastric bypass surgery. The investigators will correlate these changes to weight loss,
changes in subjective sexual function, and advanced semen parameters including DNA
fragmentation. If successful, this study will conclusively identify a new modifiable cause
for male infertility and suggest an additional medical indication for bariatric surgery in
obese infertile men.
infertility. Prior studies have shown a variety of health benefits with bariatric surgery,
including an improvement/resolution in diabetes and a significant improvement in serum
testosterone levels. Based upon preliminary data from the literature, the investigators
hypothesize that bariatric surgery is associated with a transient decrease followed by a
robust long-term improvement in semen parameters including DNA fragmentation and oxidative
stress. To test this hypothesis, the investigators propose a prospective observational study
examining changes in hormone and semen parameters over the 12 months following Roux-en-Y
gastric bypass surgery. The investigators will correlate these changes to weight loss,
changes in subjective sexual function, and advanced semen parameters including DNA
fragmentation. If successful, this study will conclusively identify a new modifiable cause
for male infertility and suggest an additional medical indication for bariatric surgery in
obese infertile men.
Inclusion Criteria:
- Men aged 18-55
- Undergoing Roux-en-Y bariatric surgery
Exclusion Criteria:
- History of undescended testes
- Prior scrotal surgery
- Known karyotypic abnormalities
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Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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