Efficacy And Safety Of Pregabalin For Pain Following Total Knee Replacement

Status:	Completed
Conditions:	Arthritis, Osteoarthritis (OA), Post-Surgical Pain
Therapuetic Areas:	Musculoskeletal, Rheumatology
Healthy:	No
Age Range:	18 - 80
Updated:	11/3/2018
Start Date:	May 2007
End Date:	December 2008

A Multicenter, Double-Blind Randomized, Placebo-Controlled Study Of The Efficacy And Safety Of Pregabalin In The Treatment Of Subjects With Post-Operative Pain Following Total Knee Arthroplasty (TKA)

Pregabalin added to the standard of care with dosing starting preoperatively and continuing
for up to 6 weeks post surgery will decrease the intensity of post-operative pain following
total knee replacement.

Inclusion Criteria:

- Subjects with osteoarthritis (OA) undergoing elective TKA under regional anesthesia
(neuroaxial with or without peripheral nerve block).

- Subjects able to demonstrate sufficient psychomotor dexterity and cognitive capacity
to use Patient Controlled Analgesia/Patient Controlled Epidural Analgesia if used as
part of the standard of care.

- The subject's preoperative health is graded as American Society of Anesthesiology
Class 1 to Class 3

Exclusion Criteria:

- Subjects undergoing revision, unicompartmental, bilateral total knee arthroplasty or
subjects with planned second knee total knee arthroplasty at time of present
procedure.

- Subjects with inflammatory arthritides (i.e., rheumatoid arthritis, lupus, ankylosing
spondylitis, psoriatic arthritis); Lyme disease.

- Subjects with fibromyalgia and or other chronic pain syndromes

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Efficacy And Safety Of Pregabalin For Pain Following Total Knee Replacement

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A Multicenter, Double-Blind Randomized, Placebo-Controlled Study Of The Efficacy And Safety Of Pregabalin In The Treatment Of Subjects With Post-Operative Pain Following Total Knee Arthroplasty (TKA)

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