Clinical Trial of Integrated Treatment for Pain and Opioid Dependence
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain, Chronic Pain, Psychiatric, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Musculoskeletal, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/2/2016 |
| Start Date: | September 2009 |
| End Date: | August 2015 |
| Contact: | Declan T Barry, PhD |
| Email: | declan.barry@yale.edu |
| Phone: | 203-285-2708 |
This study is designed to develop an effective psychotherapy for chronic pain and opioid
dependence.
dependence.
This study aims to develop a novel manualized intervention using tailored
cognitive-behavioral treatment (CBT) and buprenorphine medication to effectively treat the
co-occurring disorders of non-malignant pain and opioid dependence (POD).
Specific Aims:
1. To conduct a pre-pilot phase with 16 patients with POD receiving buprenorphine
maintenance treatment (BMT). In the pre-pilot phase, we will also explore the effects
of different daily buprenorphine dosages on pain and opiate use.
2. To conduct a pilot randomized, clinical trial to obtain data regarding the feasibility,
acceptability and efficacy (compared to Physician Management(PM) only) of manual-guided
CBT or Educational Counseling (EC) for patients with POD treated with BMT (N=75).
cognitive-behavioral treatment (CBT) and buprenorphine medication to effectively treat the
co-occurring disorders of non-malignant pain and opioid dependence (POD).
Specific Aims:
1. To conduct a pre-pilot phase with 16 patients with POD receiving buprenorphine
maintenance treatment (BMT). In the pre-pilot phase, we will also explore the effects
of different daily buprenorphine dosages on pain and opiate use.
2. To conduct a pilot randomized, clinical trial to obtain data regarding the feasibility,
acceptability and efficacy (compared to Physician Management(PM) only) of manual-guided
CBT or Educational Counseling (EC) for patients with POD treated with BMT (N=75).
Inclusion Criteria:
- 18 years of age or older
- prescription opioid addiction criteria
- moderate to severe chronic pain
- seeking or interested in buprenorphine maintenance
- understand English
Exclusion Criteria:
- methadone maintenance at a dose greater than 40 mg daily
- current suicide or homicide risk
- life-threatening or unstable medical problem
- pregnancy
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