Brain Imaging to Understand the Role of Inflammation in N-Acetyl Cysteine (NAC) Treatment of Bipolar Depression
| Status: | Recruiting |
|---|---|
| Conditions: | Depression, Depression, Psychiatric, Bipolar Disorder |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 11/7/2018 |
| Start Date: | November 1, 2018 |
| End Date: | November 1, 2019 |
| Contact: | Martin J Lan, MD PhD |
| Email: | martin.lan@nyspi.columbia.edu |
| Phone: | 646 774 7610 |
Neuroinflammation as a Novel Target to Treat Bipolar Depression: A Pilot PET Study With [11C]PBR-28 and N-Acetyl Cysteine (NAC) Antidepressant Treatment
We are trying to understand what causes bipolar disorder and how medications treat bipolar
depression. Particularly, we are looking at the importance of inflammation in the process. If
you participate, you will have two different brain scans (MRI and PET scan). You will also
have an experimental treatment for your depression named N-acetyl cysteine (NAC). The study
is funded by the Columbia University Irving Institute to improve the treatment of bipolar
disorder. Please contact us if you are interested in participating. Up to $600 in
compensation if you are eligible and choose to participate. Up to 6 months of treatment for
depression at no cost to you.
depression. Particularly, we are looking at the importance of inflammation in the process. If
you participate, you will have two different brain scans (MRI and PET scan). You will also
have an experimental treatment for your depression named N-acetyl cysteine (NAC). The study
is funded by the Columbia University Irving Institute to improve the treatment of bipolar
disorder. Please contact us if you are interested in participating. Up to $600 in
compensation if you are eligible and choose to participate. Up to 6 months of treatment for
depression at no cost to you.
Inclusion Criteria:
- Bipolar 2 disorder and meets criteria for a major depressive episode
- Age 18-60
- Females of child-bearing potential must be willing to use an acceptable method of
birth control throughout the study
- Not currently taking psychotropic medications besides those allowed in the clinical
trial
Exclusion Criteria:
- Failed trial or intolerable side effects of NAC
- Diagnosis of other major psychiatric disorders such as lifetime schizophrenia,
schizoaffective disorder, psychotic features of bipolar disorder, current drug or
alcohol abuse or recent drug or alcohol dependence
- Significant active physical illness, including blood dyscrasias, lymphomas,
hypersplenism, endocrinopathies, renal failure, chronic obstructive lung disease,
autonomic neuropathies, peripheral vascular disease. Any disorders with inflammation,
malignancy, autoimmune or infectious etiology. Systolic blood pressure >140 or
diastolic blood pressure > 100 Hemoglobin <11 in females or <13 in males
- Metal implants, pacemaker, metal prostheses, metal orthodontic appliances or shrapnel
in the body
- Current, past or anticipated exposure to radiation
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Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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