The Effects of Viscoelastometry Guided Resuscitation During Burn Excision on Post Resuscitation Infections

This is an open labeled study as the viscoelastometric (VE) guided transfusion will be based
on the visible VE results. Subjects will be randomized to receive either the standard
practice transfusion or VE guided transfusion. Blood samples, standard demographic
information, and routine laboratory data will be collected on all subjects in the Burn ICU
(BICU) enrolled in the study. VE analysis will be performed on ALL subjects immediately prior
to the burn excision, and approximately every 40 minutes while the patient is in the
operating room (OR) as well as on arrival to the BICU and every 8 hours depending on their
need for ongoing transfusion for a maximum of 24 hours. As our intervention, only the VE
based transfusion group will have access to the VE analysis at time of transfusion. The VE
results will be used at the discretion of the treating physician based on the VE guided
transfusion algorithm. Outcomes include the number and timing of blood products transfused
from the time of randomization to 24 hours post randomization and the presence of any 30 day
post-transfusion infections.

Inclusion Criteria:

- Burn patients admitted to Parkland Hospital with total burn surface area (TBSA)
greater than 20%

Exclusion Criteria:

- Patients admitted to Parkland Hospital for reasons other than burns or for burns less
than or equal to 20%