Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders

Inclusion Criteria:

- Must be treatment-seekers

- Meet criteria for alcohol use disorder

- Must be able to provide informed consent and function at an intellectual level
sufficient to allow accurate completion of all assessment instruments

- Must use one of the following methods of birth control: oral contraceptives, barrier
methods (diaphragm or condoms with spermicide or both), surgical sterilization, use of
an intra-uterine contraceptive device, or complete abstinence from sexual intercourse

- Must live within a 50-mile radius of our research program and have reliable
transportation,

- Must consent to remain abstinent from alcohol and all non-prescription drugs prior to
medication administration and testing sessions

- Must consent to fast for a two-hour period prior to medication administration

- Must consent to random assignment to the rapamycin vs. placebo conditions.

Exclusion Criteria:

- Cannot be undergoing other alcohol cessation treatment

- Cannot be pregnant, nursing, or of childbearing potential and not using birth control

- Cannot have evidence of or a history of significant endocrine, cardiovascular,
pulmonary, renal, or neurological disease

- Cannot have significant liver impairment

- Cannot have an existing infection or immune system disorder

- Cannot have a history of or current psychotic disorder, severe major depression, or
bipolar affective disorder

- Cannot currently take anti-arrythmic agents, psychostimulants, or any other agents
known to interfere with heart rate and skin conductance monitoring

- Cannot have known or suspected hypersensitivity to macrolide compounds (such as
rapamycin/sirolimus)

- Cannot currently take medications that could adversely interact with the study
medication, including but not limited to significant inhibitors of CYP2D6 or CYP3A4
(voriconazole, fluconazole, itraconazole, erythromycin, clarithromycin, diltiazem,
verapamil, etc.), or significant inducers of CYP3A4, such as anticonvulsants
(carbamazepine, phenobarbital, phenytoin, etc.) and antibiotics (rifabutin,
rifapentine, etc.)

- Cannot have a history of thrombocytopenia, idiopathic thrombocytopenia purpura (ITP)
or have a platelet count of less than 100,000 cells per mm3

- Cannot have any unhealed wounds

- Cannot have any planned surgeries within the next month, including surgical dental
procedures

- Cannot have a history of complicated alcohol withdrawal symptoms (including, but not
limited to, symptoms such as seizures, hallucinations, and high blood pressure)