Hypoxic Pulmonary Vasoconstriction Pilot Study
| Status: | Completed |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 30 - 60 |
| Updated: | 12/9/2018 |
| Start Date: | June 29, 2011 |
| End Date: | January 13, 2014 |
Pilot Study for Perfusion Heterogeneity: a Mechanistic Image-Based Emphysema Phenotype
The purpose of this study is to determine if the events leading to smoking-associated
centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent
mechanisms to block hypoxic pulmonary vasoconstriction (HPV) in areas of smoking-induced
inflammation.
centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent
mechanisms to block hypoxic pulmonary vasoconstriction (HPV) in areas of smoking-induced
inflammation.
Overall goals of this study are to 1) determine the effects on sildenafil on the
heterogeneity perfused blood volume in smokers susceptible to emphysema using dual energy CT
2) utilize pulmonary blood volume heterogeneity as an image-based biomarker to differentiate
normal and susceptible smokers.
heterogeneity perfused blood volume in smokers susceptible to emphysema using dual energy CT
2) utilize pulmonary blood volume heterogeneity as an image-based biomarker to differentiate
normal and susceptible smokers.
Inclusion Criteria:
- Must be between the ages of 30 and 60.
- Must be currently smoking at least 1/2 pack/day (confirmed with cotinine level).
- Must have pulmonary function test (PFT) results that meet the following:
- Forced Expiratory Volume at one second (FEV1)/Forced Vital Capacity (FVC) > 70%
- Forced Expiratory Flow at 25-75% (FEF25-75) > 79% of predicted
- FVC greater than 80% of predicted
- Must be able to give informed consent for self.
Exclusion Criteria:
- Pregnant or breastfeeding females.
- Body Mass Index (BMI) greater than 32.
- Weight of greater than 220 pounds (100 kg).
- Allergies to shell fish, seafood, eggs or iodine.
- Heart disease, kidney disease or diabetes.
- Diagnosis of asthma.
- Usage of any medications that are known to affect the heart or lungs (contraceptives,
anti-depressants, analgesics EXCEPT aspirin, antihypertensives, and medications for
osteoporosis and gastrointestinal diseases will be allowed).
- Any metal in or on the body between the nose and the abdomen.
- Any major organ system disease (by judgment of study medical team).
For the subjects that will receive Sildenafil as part of the study, additional exclusion
criteria are as follows:
- Nitroglycerin usage.
- Prior history of hypersensitivity to Sildenafil.
We found this trial at
1
site
University of Iowa With just over 30,000 students, the University of Iowa is one of...
Click here to add this to my saved trials
