A Study to Investigate CSL312 in Subjects With Hereditary Angioedema (HAE)

Inclusion Criteria:

- Male or female

- Aged ≥ 18 to ≤ 65 years

- A diagnosis of C1-INH HAE or FXII/PLG HAE;

- For subjects with C1-INH HAE: ≥ 4 HAE attacks over a consecutive 2-month period during
the 3 months before Screening, as documented in the subject's medical record.

Exclusion Criteria:

- History of clinically significant arterial or venous thrombosis, or current clinically
significant prothrombotic risk

- History of an uncontrolled, abnormal bleeding event due to a coagulopathy, or a
current clinically significant coagulopathy or clinically significant risks for
bleeding events

- Known incurable malignancies