Multi-joint Muscle Fatigability and Gait Performance in People With Multiple Sclerosis
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Other Indications, Neurology, Neurology, Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 85 |
| Updated: | 11/10/2018 |
| Start Date: | November 15, 2018 |
| End Date: | October 1, 2021 |
| Contact: | Michael Harris-Love, DSc |
| Email: | michael.harris-love@va.gov |
| Phone: | (202) 745-8240 |
Assessing the Impact of Muscle Strength and Fatigability on Gait Performance Using Single Joint and Multi-joint Assessments in People With Multiple Sclerosis
The purpose of this study is to compare walking to leg strength and endurance in people with
multiple sclerosis (PwMS). Using these findings, we hope to be better understand what causes
PwMS to have problems walking.
multiple sclerosis (PwMS). Using these findings, we hope to be better understand what causes
PwMS to have problems walking.
The purposes of the research are to determine the association of gait performance with lower
extremity muscle fatigability and strength measures, and create a preliminary model that can
better explain the variance in gait performance based on these muscle performance values.
Objective criterion-based measures of physical fatigue (i.e., fatigability) and muscle
weakness have been associated with impaired task performance in people with multiple
sclerosis (MS). MS-related deficits in muscle capacity result in higher fall risks and a loss
of function. However, it is unclear if lower extremity fatigability tests add clinical value
to objective strength testing in the rehabilitation and clinical management of MS. Better
understanding how patterns of lower extremity (LE) fatigability and strength affect mobility
in people with MS could improve outcome measure development and inform rehabilitation
strategies.
extremity muscle fatigability and strength measures, and create a preliminary model that can
better explain the variance in gait performance based on these muscle performance values.
Objective criterion-based measures of physical fatigue (i.e., fatigability) and muscle
weakness have been associated with impaired task performance in people with multiple
sclerosis (MS). MS-related deficits in muscle capacity result in higher fall risks and a loss
of function. However, it is unclear if lower extremity fatigability tests add clinical value
to objective strength testing in the rehabilitation and clinical management of MS. Better
understanding how patterns of lower extremity (LE) fatigability and strength affect mobility
in people with MS could improve outcome measure development and inform rehabilitation
strategies.
Inclusion Criteria:
- Age 18-85 years
- History of multiple sclerosis
- Expanded Disability Status Scale < 7.0
- Receives care at the Washington DC Veteran's Affairs Medical Center Neurology Service
and Multiple Sclerosis Center of Excellence - East
We found this trial at
1
site
Washington, District of Columbia 20422
Principal Investigator: Michael Harris-Love, DSc
Phone: 202-745-8000
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