A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 12 - Any |
| Updated: | 4/3/2019 |
| Start Date: | October 9, 2018 |
| End Date: | June 2021 |
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy in Subjects With Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation
This study will evaluate the long-term safety and tolerability of VX-445 in triple
combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis
(CF) who are homozygous or heterozygous for the F508del mutation
combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis
(CF) who are homozygous or heterozygous for the F508del mutation
Inclusion Criteria:
- Completed study drug treatment in a parent study; or had study drug interruption(s) in
a parent study but completed study visits up to the last scheduled visit of the
Treatment Period in the parent study.
Exclusion Criteria:
- History of drug intolerance in a parent study that would pose an additional risk to
the subject in the opinion of the investigator.
- Current participation in an investigational drug trial (other than a parent study)
Other protocol defined Inclusion/Exclusion criteria may apply.
We found this trial at
49
sites
National Jewish Health National Jewish Health is known worldwide for treatment of patients with respiratory,...
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Akron Children's Hospital From humble beginnings as a day nursery in 1890, Akron Children
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4900 Mueller Boulevard
Austin, Texas 78723
Austin, Texas 78723
(512) 324-0000
Dell Children's Medical Center of Central Texas Welcome to Dell Children
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Nationwide Children's Hospital At Nationwide Children’s, we are creating the future of pediatric health care....
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529 West Markham Street
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
(501) 686-7000
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
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Childrens Hospital Los Angeles Children's Hospital Los Angeles is a 501(c)(3) nonprofit hospital for pediatric...
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601 Children's Lane
Norfolk, Virginia 23507
Norfolk, Virginia 23507
(757) 668-7000
Children's Hospital of The King's Daughters Children
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Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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New York Medical College The College was founded in 1860 by a group of New...
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Boston, Massachusetts 02114
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171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Northwestern Memorial Hospital Northwestern Memorial is an academic medical center hospital where the patient comes...
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Cleveland, Ohio 44106
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University of Texas Southwestern Medical Center UT Southwestern is an academic medical center, world-renowned for...
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University of Kansas Medical Center The University of Kansas Medical Center serves Kansas through excellence...
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Minneapolis, Minnesota 55404
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West Virginia University West Virginia University, founded in 1867, has a long and rich history...
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940 NE 13th St
Oklahoma City, Oklahoma 73190
Oklahoma City, Oklahoma 73190
(405) 271-6458
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
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Nebraska Medical Center Formed in 1997 by combining the operations of University Hospital, Bishop Clarkson...
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Nemours Children's Hospital Nemours Children's Hospital in Orlando brings pediatric specialty care never before offered...
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Peoria, Illinois 61637
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1000 East Broad Street
Richmond, Virginia 23298
Richmond, Virginia 23298
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1 Tampa General Circle
Tampa, Florida 33606
Tampa, Florida 33606
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Toledo, Ohio 43606
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