Theta Burst Stimulation in Young Adults With Depression
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Depression, Depression |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 25 |
| Updated: | 3/27/2019 |
| Start Date: | May 2019 |
| End Date: | November 2020 |
| Contact: | Erika E Forbes, Ph.D. |
| Email: | forbese@upmc.edu |
| Phone: | 412-383-5438 |
For the proposed 2-year study, the investigators will conduct a within-subject,
counterbalanced investigation using functional magnetic resonance imaging (fMRI) and
transcranial magnetic stimulation (TMS) to examine the acute effects of theta-burst
stimulation (TBS) on function in dorsomedial prefrontal cortex (dmPFC) in 35 young adults
with depression (18-25 years, 50% female).
counterbalanced investigation using functional magnetic resonance imaging (fMRI) and
transcranial magnetic stimulation (TMS) to examine the acute effects of theta-burst
stimulation (TBS) on function in dorsomedial prefrontal cortex (dmPFC) in 35 young adults
with depression (18-25 years, 50% female).
Each participant will undergo 3 sessions of TMS, one each of continuous and intermittent
TBS--with the goal of decreasing or increasing dmPFC responding, respectively--and one of
sham TBS. Session order will be counterbalanced, with a double-blind approach to condition.
Brain function, behavior, and mood will be assessed before and after each TBS session.
Broadly, the investigators predict that inhibitory TBS to the dmPFC will enhance neural,
behavioral, and subjective aspects of reward function by reducing dmPFC function and dmPFC
connectivity with the ventral striatum (VS).
TBS--with the goal of decreasing or increasing dmPFC responding, respectively--and one of
sham TBS. Session order will be counterbalanced, with a double-blind approach to condition.
Brain function, behavior, and mood will be assessed before and after each TBS session.
Broadly, the investigators predict that inhibitory TBS to the dmPFC will enhance neural,
behavioral, and subjective aspects of reward function by reducing dmPFC function and dmPFC
connectivity with the ventral striatum (VS).
Inclusion Criteria:
• DSM-5 Diagnosis of Major Depressive Disorder, Persistent Depressive Disorder (Dysthymia),
Other Specified Depressive Disorder, or Other Unspecified Depressive Disorder
Exclusion Criteria:
- Bipolar disorder, substance dependence, or lifetime history of psychosis
- Neurological disorder (e.g., seizure disorder)
- Pregnant
- MRI contradictions: claustrophobia, permanent orthodontic devices, metal implants or
other forms of metal in the body that cannot be removed
We found this trial at
1
site
Pittsburgh, Pennsylvania 15213
Principal Investigator: Erika E Forbes, Ph.D.
Phone: 412-383-5438
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