Study of Safety and Efficacy of Brolucizumab 6 mg Dosed Every 4 Weeks Compared to Aflibercept 2 mg Dosed Every 4 Weeks in Patients With Retinal Fluid Despite Frequent Anti-VEGF Injections
| Status: | Recruiting |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 2/23/2019 |
| Start Date: | October 30, 2018 |
| End Date: | June 9, 2020 |
| Contact: | Novartis Pharmaceuticals |
| Email: | novartis.email@novartis.com |
| Phone: | 1-888-669-6682 |
A Multicenter, Randomized, Double-masked Phase 3a Study to Assess Safety and Efficacy of Brolucizumab 6 mg q4 Weeks Compared to Aflibercept 2 mg q4 Weeks in Patients With Neovascular Age-related Macular Degeneration (nAMD) With Persistent Retinal Fluid (MERLIN)
The purpose of this study is to compare safety and efficacy of brolucizumab 6 mg dosed every
4 weeks to aflibercept 2 mg dosed every 4 weeks in those nAMD patients with retinal fluid
despite frequent anti-Vascular Endothelial Growth Factor (VEGF) injections.
4 weeks to aflibercept 2 mg dosed every 4 weeks in those nAMD patients with retinal fluid
despite frequent anti-Vascular Endothelial Growth Factor (VEGF) injections.
Inclusion Criteria:
- Sign informed consent
- Diagnosis of wet age-related macular degeneration (AMD)
- Currently receiving anti-VEGF injections
Exclusion Criteria:
- Active infection or inflammation in either eye
- Significant fibrosis in the study eye
- Recent ocular surgery
- Uncontrolled glaucoma
- Previous treatment with brolucizumab in the study eye
- Use of medications as specified in the protocol
- Pregnant, nursing
- Of child-bearing potential unless using highly effective method of contraception
Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
39
sites
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Novartis Novartis, which was created in 1996 by the merger of the Swiss companies Ciba-Geigy...
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