A Study of Participants With Relapsing-Remitting Multiple Sclerosis (RRMS)



Status:Completed
Conditions:Neurology, Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 64
Updated:11/17/2018
Start Date:April 2009
End Date:June 2012

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Multiple Subcutaneous Doses of LY2127399, an Anti-BAFF Human Antibody, in Subjects With Relapsing-Remitting Multiple Sclerosis

To look at the ability of LY2127399 to reduce magnetic resonance imaging (MRI) lesions at 12,
16, 20, and 24 weeks compared to placebo.


Inclusion Criteria:

- 18 through 64 years of age diagnosed with RRMS, who can walk without aid or rest for
at least 200 meters (approximately 1/10 of a mile).

- Women who can become pregnant must use birth control.

Exclusion Criteria:

- Have had a live vaccination within 12 weeks before randomization, or intend to have a
live vaccination during the course of the study.

- Have had had recent surgery or are scheduled to have surgery during the study.

- Are immunocompromised or have evidence of active infection [such as hepatitis,
tuberculosis or, human immunodeficiency virus (HIV)].

- Have been on certain drugs that are being studied for RRMS or have recently received
prescription drugs to treat RRMS.

- Have had a recent serious infection.

- Have serious or uncontrolled illnesses other than RRMS.

- Have clinically significant blood test values.

- Have multiple or severe drug allergies.

- Have contraindications for MRI "scanning" or claustrophobia (fear of an enclosed
space) that cannot be managed.
We found this trial at
28
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Charlotte, North Carolina 28207
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Farmington Hills, Michigan 48334
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Greenville, South Carolina 29605
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