A Food Effect Study in Healthy Volunteers With PT2977 Tablets

Subjects will be randomized in equal numbers to two sequences of meal conditions (fasting and
non-fasting). Serial blood samples will be collected after dose administration in each
period. Subjects will be confined at the clinical research for a portion of each period.

Inclusion Criteria:

- Female or vasectomized male;

- If of childbearing potential, willing to practice methods of birth control;

- If of childbearing potential, must be non-pregnant and non-lactating and have a
negative serum pregnancy test result prior to enrollment into the trial;

- Has a body mass index (BMI) between 19 and 32 kg/m2; Willing and able to give written
informed consent for study participation and provide consent for access to medical
data;

- Willing and able to cooperate with all aspects of the protocol.

Exclusion Criteria:

- Any vaccination within 30 days before start of this study and throughout the study;

- Abnormal blood pressure or pulse rate;

- Abnormal screening electrocardiogram (ECG);

- Receipt of any investigational agent within 30 days;

- A positive history of drug abuse or a positive test result for drug(s) of abuse;

- Female subjects who are planning a pregnancy or are pregnant or lactating.