FMISO PET/CT Imaging Trial for Assessing Hypoxia in Soft Tissue Sarcomas
| Status: | Recruiting |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/21/2019 |
| Start Date: | February 1, 2019 |
| End Date: | February 1, 2022 |
| Contact: | Katherin Mendez |
| Email: | Katherin.Mendez@uphs.upenn.edu |
| Phone: | 215-573-6693 |
Integrated Biomarker PET/CT Imaging Trial for Assessing Hypoxia in Soft Tissue Sarcomas Using a Novel PET/CT Tracer
Subjects with known or suspected primary soft tissue sarcoma of the extremities may be
eligible for this study. Subjects may participate in this study if they are at least 18 years
of age. Most participants will be receiving care at the clinical practices of the University
of Pennsylvania Health System.
Positron emission tomography (PET/CT) imaging will be used to evaluate soft tissue sarcoma
hypoxia using an investigational radiotracer, 18F-FMISO Subjects will also undergo an 18F-FDG
PET/CT scan close to the time of their initial hypoxia PET/CT to compare in vivo measures of
hypoxia to 18F-FDG uptake. The FDG PET/CT may be performed as part of standard clinical care
or as a research scan. Both PET/CT scans will occur prior to starting new therapy.
eligible for this study. Subjects may participate in this study if they are at least 18 years
of age. Most participants will be receiving care at the clinical practices of the University
of Pennsylvania Health System.
Positron emission tomography (PET/CT) imaging will be used to evaluate soft tissue sarcoma
hypoxia using an investigational radiotracer, 18F-FMISO Subjects will also undergo an 18F-FDG
PET/CT scan close to the time of their initial hypoxia PET/CT to compare in vivo measures of
hypoxia to 18F-FDG uptake. The FDG PET/CT may be performed as part of standard clinical care
or as a research scan. Both PET/CT scans will occur prior to starting new therapy.
Inclusion Criteria:
1. Known or suspected soft tissue sarcoma seen on at least one type of standard imaging
(e.g. CT, ultrasound, MRI, or 18F-FDG PET/CT)
2. At least 18 years of age
3. Subjects with local disease or advanced/metastatic disease will be eligible
4. Willing to consent to use of tissue from biopsy or surgery for the purposes of this
study
5. Participants must be informed of the investigational nature of this study and be
willing and able to provide written informed consent and participate in this study in
accordance with institutional and federal guidelines prior to study-specific
procedures.
Exclusion Criteria:
1. Females who are pregnant at the time of screening will not be eligible for this study;
a urine pregnancy test will be performed at screening in women of child-bearing
potential
2. Inability to tolerate imaging procedures in the opinion of an investigator or treating
physician
3. Serious or unstable medical or psychological conditions that, in the opinion of the
investigator, would compromise the subject's safety or successful participation in the
study
We found this trial at
1
site
3451 Walnut St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-573-6693
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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