Satiety and Glucose Indices in Adults

Subjects are randomly assigned (double blinded) to 300 mg SC, 500 mg SC or placebo using a
cross-over design on three different days (1 month wash out). Subjects consuming a capsule
containing placebo or treatment(s) are examined before and after a fixed breakfast meal (50%
carbohydrate; 30% fat; 20% protein).

Subjective appetite sensations are rated using visual analog scales (VAS) for hunger,
satiety, fullness, and prospective food intake. In addition, the desire for specific tastes
is analyzed and measurements are taken twice before breakfast (fasting baseline). After
baseline screening and blood draw, postprandial appetite and taste perception ratings and
blood will be obtained at multiple time points during the 3 hour postprandial period (30, 60,
90, 120,180 min). Blood will be analyzed for glucose/insulin, gut peptides, and other markers
in response to the meal.

Inclusion Criteria:

- BMI - overweight or stage 1 obesity

- Must be willing and able to visit the geographic vicinity of New Brunswick, NJ

Exclusion Criteria:

- (BP) [systolic BP> 140 and/or diastolic BP> 90]

- Fasting blood glucose >126

- Subject has a significant history or current presence of treated or untreated bleeding
disorder, diabetes mellitus, thyroid disease, tachyarrhythmia, heart disease, kidney
disease, or liver disease.

- History of chronic conditions and on prescription medication, surgery and or any
treatment

- Any significant GI condition that would severely interfere with the evaluation of the
study product including but not limited to inflammatory bowel disease (Ulcerative
Colitis or Crohn's), history of frequent diarrhea, history of surgery for weight loss
(including gastric bypass or lapband), history of perforation of the stomach or
intestines, gastroparesis, clinically important lactose intolerance

- History or presence of all cancers in the prior two years.

- Participation in a clinical study with exposure to any registered and non-registered
drug product within 30 days prior.

- Pregnant or lactating women.

- Subjects who are currently on any weight loss diets, weight loss regimen

- Subjects currently taking prescription medication for hypertension, cardiovascular
disease, diabetes and/or other chronic conditions.

- Subject currently suffers from a sleep disorder and/or has a known history of (or is
currently being treated for) clinical depression, eating disorder(s) or any other
psychiatric condition(s), which in the opinion of the investigator, might put the
subject at risk and/or confound the results of the study.

- Subject has a known allergy or sensitivity to any ingredient in the test product.

- Subject has any medical condition or uses any medication, nutritional product, dietary
supplement or program, which in the opinion of the investigator, might interfere with
the conduct of the study or place the subject at risk.

- Subject has a history of difficulty swallowing large pills or tablets.

- Investigator is uncertain about subject's capability or willingness to comply with the
protocol requirements.