Diffuse Optical Monitoring With Inhaled Nitric Oxide

Inclusion Criteria:

Stroke Patients:

1. Age greater than 18

2. Acute ischemic stroke in the territory of the anterior, middle, or posterior cerebral
artery, on either side of the brain

3. Study can be initiated within 72 hours of stroke symptom onset

3. Ability and willingness to sign informed consent

Healthy subjects:

1. Age greater than 18

2. Ability and willingness to sign informed consent

Exclusion Criteria:

Stroke subjects:

1. History of prior stroke or transient ischemic attack

2. Known cerebrovascular abnormality

3. History of congestive heart failure

4. Presence of pneumonia or active pulmonary infection

5. Current use of any NO donor medication (sodium nitroprusside or nitroglycerin)

6. Age less than 18 years

7. Skull defect that would interfere with CBF monitoring

8. Pregnancy

9. Structural brain lesion

10. Prior neurosurgical procedure

11. History of psychiatric disease

12. Any medical condition that the clinical investigator feels would pose a hazard to the
subject if he/she participated in the study

Healthy subjects:

1. History of any neurological disease

2. History of stroke or transient ischemic attack

3. Known cerebrovascular abnormality

4. History of congestive heart failure

5. History of chronic pulmonary disease such as asthma or chronic obstructive pulmonary
disease

6. Presence of pneumonia or active pulmonary infection

7. Current use of any NO donor medication (sodium nitroprusside or nitroglycerin)

8. Age less than 18 years

9. Skull defect that would interfere with CBF monitoring

10. Pregnancy (urine or blood tests will not be performed)

11. Structural brain lesion

12. Prior neurosurgical procedure

13. History of psychiatric disease

14. Any medical condition that the clinical investigator feels would pose a hazard to the
subject if he/she participated in the study

15. Cognitive impairment