Increasing Human Papillomavirus (HPV) Vaccine Uptake Via General Health Messaging
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 12/1/2018 |
| Start Date: | April 25, 2018 |
| End Date: | June 2019 |
Background: Prevention of cervical cancer and genital warts could be achieved by immunization
with the prophylactic human papillomavirus (HPV) vaccines commercially available. However, in
the U.S. only 38% of females and 14% of males in the recommended age group (9-26 years)
receive the complete, three-dose HPV vaccine. Because the HPV vaccine is covered under the
Vaccine for Children Program, the underinsured and uninsured have no-cost access.
Nonetheless, data from Los Angeles county suggest that HPV vaccination rates among the
uninsured and underinsured groups are significantly lower than the national average, likely
related to knowledge of the vaccine, transportation, number of doses and concern of side
effects.
Aim: To evaluate the efficacy of health oriented text messaging to increase HPV vaccine
uptake versus standard health messaging (Center for Disease Control and Prevention (CDC) HPV
vaccine information flyers).
Hypothesis: We hypothesize that receiving general health messaging, including messages
regarding the benefits of the HPV vaccine, will increase HPV vaccine uptake. Text messaging
will also be more successful in reaching the uninsured and underinsured populations than will
traditional flyers/information pamphlets used in clinics.
Methods: A cluster randomized trial design will be used to recruit participants from four
clinics in Los Angeles County which offer pediatric vaccination to uninsured and underinsured
children. The sample will include women aged 18-45 years of age. Two of the sites will be
randomized to the text messaging arm and the other clinic will be randomized to the control
arm (standard messaging: CDC flyers and pamphlets available for patients at the clinic).
Outcome measures will be HPV vaccinations rates at those clinics. Rates will be defined into
groups who received 1 dose, 2 doses and 3 doses.
Anticipated Results: We expect to find statistically significant higher HPV vaccination rates
among children and women in the text messaging study arm compared to the control arm.
Implications and Future Studies: This pilot study will give us preliminary data to submit a
larger randomized controlled trial to examine the efficacy of text messaging.
with the prophylactic human papillomavirus (HPV) vaccines commercially available. However, in
the U.S. only 38% of females and 14% of males in the recommended age group (9-26 years)
receive the complete, three-dose HPV vaccine. Because the HPV vaccine is covered under the
Vaccine for Children Program, the underinsured and uninsured have no-cost access.
Nonetheless, data from Los Angeles county suggest that HPV vaccination rates among the
uninsured and underinsured groups are significantly lower than the national average, likely
related to knowledge of the vaccine, transportation, number of doses and concern of side
effects.
Aim: To evaluate the efficacy of health oriented text messaging to increase HPV vaccine
uptake versus standard health messaging (Center for Disease Control and Prevention (CDC) HPV
vaccine information flyers).
Hypothesis: We hypothesize that receiving general health messaging, including messages
regarding the benefits of the HPV vaccine, will increase HPV vaccine uptake. Text messaging
will also be more successful in reaching the uninsured and underinsured populations than will
traditional flyers/information pamphlets used in clinics.
Methods: A cluster randomized trial design will be used to recruit participants from four
clinics in Los Angeles County which offer pediatric vaccination to uninsured and underinsured
children. The sample will include women aged 18-45 years of age. Two of the sites will be
randomized to the text messaging arm and the other clinic will be randomized to the control
arm (standard messaging: CDC flyers and pamphlets available for patients at the clinic).
Outcome measures will be HPV vaccinations rates at those clinics. Rates will be defined into
groups who received 1 dose, 2 doses and 3 doses.
Anticipated Results: We expect to find statistically significant higher HPV vaccination rates
among children and women in the text messaging study arm compared to the control arm.
Implications and Future Studies: This pilot study will give us preliminary data to submit a
larger randomized controlled trial to examine the efficacy of text messaging.
Prevention of cervical cancer and genital warts could be achieved by immunization with the
prophylactic human papillomavirus (HPV) vaccines commercially available. However, in the U.S.
only 38% of females and 14% of males in the recommended age group (9-26 years) receive the
complete, three-dose HPV vaccine. Because the HPV vaccine is covered under the Vaccine for
Children Program, the underinsured and uninsured have no-cost access. Nonetheless, data from
Los Angeles county suggest that HPV vaccination rates among the uninsured and underinsured
groups are significantly lower than the national average, likely related to knowledge of the
vaccine, transportation, number of doses and concern of side effects. The primary objective
of this pilot study is to evaluate the efficacy of health oriented text messaging to increase
HPV vaccine uptake versus standard health messaging (Center for Disease Control and
Prevention (CDC) HPV vaccine information flyers).
We hypothesize HPV vaccine uptake will be improved through the receipt of general health
messaging that includes HPV vaccine messages. Such messaging will increase knowledge about
HPV vaccine availability, as well as improve the perceptions around HPV vaccination. Text
messaging will also be more successful in reaching large population groups than traditional
flyers/information pamphlets used in clinics.
First, among our three participating clinics, we convened community advisory boards (CABs) of
individuals who are English and Spanish speaking to identify appropriate text messages
including content, length of message and frequency of messaging (once a week, every other
week). Topics included HPV vaccine messages, contraceptive information on hormonal
contraception, long-acting reversible contraceptive (LARC) methods, dysmenorrhea, frequent
menses, and vaginal discharge. We focused on all topics and specifically messaging of HPV
vaccine that are considered neutral and yet compelling. We built upon the feedback obtained
from the CAB. Each clinic serves at least 500 uninsured and underinsured children that offer
regular HPV vaccination to these children. Of these three clinics, two of the sites will be
randomized to the intervention arm (text messaging) and 1 site to have CDC flyers only. The
sites currently collect information on all immunization given at their site. The sites will
de-identify their vaccine rates for HPV at the end of the study and send us the de-identified
data sets for vaccine rates, age (not birth date) and number of nursing/doctor visits made by
age group.
prophylactic human papillomavirus (HPV) vaccines commercially available. However, in the U.S.
only 38% of females and 14% of males in the recommended age group (9-26 years) receive the
complete, three-dose HPV vaccine. Because the HPV vaccine is covered under the Vaccine for
Children Program, the underinsured and uninsured have no-cost access. Nonetheless, data from
Los Angeles county suggest that HPV vaccination rates among the uninsured and underinsured
groups are significantly lower than the national average, likely related to knowledge of the
vaccine, transportation, number of doses and concern of side effects. The primary objective
of this pilot study is to evaluate the efficacy of health oriented text messaging to increase
HPV vaccine uptake versus standard health messaging (Center for Disease Control and
Prevention (CDC) HPV vaccine information flyers).
We hypothesize HPV vaccine uptake will be improved through the receipt of general health
messaging that includes HPV vaccine messages. Such messaging will increase knowledge about
HPV vaccine availability, as well as improve the perceptions around HPV vaccination. Text
messaging will also be more successful in reaching large population groups than traditional
flyers/information pamphlets used in clinics.
First, among our three participating clinics, we convened community advisory boards (CABs) of
individuals who are English and Spanish speaking to identify appropriate text messages
including content, length of message and frequency of messaging (once a week, every other
week). Topics included HPV vaccine messages, contraceptive information on hormonal
contraception, long-acting reversible contraceptive (LARC) methods, dysmenorrhea, frequent
menses, and vaginal discharge. We focused on all topics and specifically messaging of HPV
vaccine that are considered neutral and yet compelling. We built upon the feedback obtained
from the CAB. Each clinic serves at least 500 uninsured and underinsured children that offer
regular HPV vaccination to these children. Of these three clinics, two of the sites will be
randomized to the intervention arm (text messaging) and 1 site to have CDC flyers only. The
sites currently collect information on all immunization given at their site. The sites will
de-identify their vaccine rates for HPV at the end of the study and send us the de-identified
data sets for vaccine rates, age (not birth date) and number of nursing/doctor visits made by
age group.
Inclusion Criteria:
- Women who are patients at the clinic
- Age 18+
- Have a working mobile phone with SMS capability
Exclusion Criteria:
- Male
- <18 years of age
- Do not have a working mobile phone with SMS capability
We found this trial at
1
site
University of California at Los Angeles The University of California, Los Angeles (UCLA) is an...
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