Does Propanolol, a Beta Blocker, Attenuate Stress-Induced Drinking?
| Status: | Recruiting |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 12/2/2018 |
| Start Date: | September 15, 2018 |
| End Date: | July 31, 2019 |
| Contact: | Sabrina Coppola |
| Email: | sabrina.coppola@yale.edu |
| Phone: | 203-737-2827 |
For this protocol, the investigators plan to conduct a pilot study evaluating the effect of
propranolol on alcohol consumption. Using a parallel design, the investigators plan to
randomize 20 non-treatment seeking adults with alcohol use disorders (DSM-5) to propranolol
extended release (160mg/day or placebo; n=10 per cell) to evaluate whether propranolol
reduces alcohol self-administered in the laboratory. Importantly, the investigators will
evaluate whether propranolol counteracts stress-induced effects on alcohol
self-administration. Following titration to steady state medication levels over a 2-week
period, each subject will complete two laboratory sessions consisting of a well validated
method for inducing stress or neutral/relaxing state (order counterbalanced), followed by a
2-hour alcohol self-administration paradigm known to be sensitive to medication effects.
propranolol on alcohol consumption. Using a parallel design, the investigators plan to
randomize 20 non-treatment seeking adults with alcohol use disorders (DSM-5) to propranolol
extended release (160mg/day or placebo; n=10 per cell) to evaluate whether propranolol
reduces alcohol self-administered in the laboratory. Importantly, the investigators will
evaluate whether propranolol counteracts stress-induced effects on alcohol
self-administration. Following titration to steady state medication levels over a 2-week
period, each subject will complete two laboratory sessions consisting of a well validated
method for inducing stress or neutral/relaxing state (order counterbalanced), followed by a
2-hour alcohol self-administration paradigm known to be sensitive to medication effects.
Inclusion Criteria:
1. Age 21-65
2. Able to read and write English
3. Meets Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for
current (past 6 months) alcohol use disorders
4. Able to take oral medications and willing to adhere to medication regimen
Exclusion Criteria:
1. Participants with any significant current medical conditions.
2. Women who are pregnant or nursing, or fail to use one of the following methods of
birth control unless she or partner is surgically sterile or she is postmenopausal
(hormone contraceptives [oral, implant, injection, patch, or ring], contraceptive
sponge, double barrier [diaphragm or condom plus spermicide], or IUD)
3. Suicidal, homicidal or evidence of current (past 6-month) mental illness.
4. Specific exclusions for administration of propranolol not already specified.
5. Subjects likely to exhibit clinically significant alcohol withdrawal during the study.
We found this trial at
1
site
333 Cedar St
New Haven, Connecticut 06504
New Haven, Connecticut 06504
(203) 432-4771
Phone: 203-737-2827
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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