A Study of Deflazacort (Emflaza®) in Participants With Duchenne Muscular Dystrophy (DMD)
| Status: | Withdrawn |
|---|---|
| Conditions: | Neurology, Orthopedic |
| Therapuetic Areas: | Neurology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 2 - 4 |
| Updated: | 1/19/2019 |
| Start Date: | October 31, 2018 |
| End Date: | July 31, 2021 |
A 52-Week Phase 3B Randomized Open-Label Study Evaluating the Safety and Pharmacokinetics of Emflaza® (Deflazacort) Compared to a Comparable Natural History Control Group in Males Aged ≥2 to <5 Years With Duchenne Muscular Dystrophy (DMD) Followed by a 52-Week Extension Period
The primary objective of this study is to evaluate the safety of a 0.9 milligrams per
kilogram (mg/kg) and 0.45 mg/kg daily dose of deflazacort with a comparable natural history
control group after 52 weeks of treatment in males with DMD aged greater than or equal to
(>=) 2 to lesser than (<) 5 years.
The study will comprise of 2 periods (Period 1: 52-week safety and pharmacokinetics [PK], and
Period 2: 52-week extension). Participants will be randomized in a 1:1 ratio to one of 2
treatment arms: 0.9 mg/kg deflazacort, and 0.45 mg/kg of deflazacort. A historic control
group (which should match the study population as closely as possible) will be used as a
comparator to characterize the safety and tolerability of deflazacort.
kilogram (mg/kg) and 0.45 mg/kg daily dose of deflazacort with a comparable natural history
control group after 52 weeks of treatment in males with DMD aged greater than or equal to
(>=) 2 to lesser than (<) 5 years.
The study will comprise of 2 periods (Period 1: 52-week safety and pharmacokinetics [PK], and
Period 2: 52-week extension). Participants will be randomized in a 1:1 ratio to one of 2
treatment arms: 0.9 mg/kg deflazacort, and 0.45 mg/kg of deflazacort. A historic control
group (which should match the study population as closely as possible) will be used as a
comparator to characterize the safety and tolerability of deflazacort.
Inclusion Criteria:
- In the opinion of the Investigator, the participant and parent(s)/caregiver are
capable of complying with protocol requirements.
- The participant's legally acceptable representative signs and dates a written informed
consent form and any required privacy authorization prior to the initiation of any
study procedures.
- The participant must have a diagnosis of DMD defined by genetic or biopsy confirmation
of DMD or have documented, increased serum creatine kinase more than 40 times the
upper limit of normal (ULN) and shown phenotypic signs of DMD.
- The participant weighs between 11 kilograms (kg) and 50 kg at screening visit.
- Ability to comply with scheduled visits, oral drug administration, and study
procedures.
- The participant is current on childhood vaccinations according to the Center for
Disease Control (CDC) recommended immunizations for children from birth through 6
years old. Note: The investigator should discuss timing of receipt of the varicella
vaccine with the caregiver prior to initiation of chronic steroid treatment.
Administration of live or live attenuated vaccines is not recommended in participants
receiving immunosuppressive doses of corticosteroids. Participants whose caregivers
decline vaccinations as a matter of personal belief may be included.
- Baseline health is judged to be stable based on medical history, physical examination,
laboratory profiles, and vital signs at screening, as deemed by the Investigator.
- The participant is able to ingest the oral tablets either whole or crushed.
Exclusion Criteria:
- The participant has received 4 weeks or more of continuous corticosteroid therapy
within 3 months of study screening visit.
- The participant has, in the judgment of the Investigator, clinically significant
abnormal clinical laboratory parameters at screening or baseline that may affect
safety.
- The participant has, in the judgment of the Investigator, a history or current medical
condition that could affect safety including, but not limited to:
1. Major renal or hepatic impairment
2. Immunosuppression or other contraindications for corticosteroid treatment
3. History of chronic systemic fungal or viral infections
4. Diabetes mellitus or significant glucose intolerance
5. Idiopathic hypercalciuria
6. Symptomatic cardiomyopathy Note: Elective surgeries can be discussed with medical
monitor.
- The participant has a history of hypersensitivity or allergic reaction to steroids or
their formulations including, but not limited to lactose, sucrose, etc.
- The participant has received any drug, including prescription and non-prescription
medications, and herbal remedies known to be significant inhibitors and/or inducers of
cytochrome P3A4 (CYP3A4) enzymes and/or P glycoprotein (P-gp) 14 days prior to the
first dose of study drug.
- The participant has an indication that requires long-term use of strong CYP3A4
inhibitors and/or inducers that would interfere with the pharmacokinetics of
deflazacort.
- The participant has received any investigational compound and/or has participated in
another clinical study within 30 days prior to study treatment with the exception of
observational cohort studies or non-interventional studies.
We found this trial at
1
site
Atlanta, Georgia 30318
Principal Investigator: Han Phan
Phone: 404-883-2724
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