Collagen Cross-linking in Keratoconus
| Status: | Recruiting |
|---|---|
| Conditions: | Ocular, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery, Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/2/2018 |
| Start Date: | June 20, 2018 |
| End Date: | December 2023 |
| Contact: | Denzil Romfh, OD |
| Email: | romfhd@ohsu.edu |
| Phone: | 503-494-4351 |
Clinical Trial of Laser Custom Corneal Collagen Cross-Linking in Keratoconus
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the
depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in
patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly
decreases corneal aberrations and improves vision. This study will use OCT-guided setting for
the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess
the affect on visual outcomes.
depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in
patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly
decreases corneal aberrations and improves vision. This study will use OCT-guided setting for
the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess
the affect on visual outcomes.
In the U.S., CXL and topography-guided laser ablation were approved independently, but not
together. Another variation in technique involves the use of mitomycin-C (MMC), which is
effective in reducing corneal haze after the laser surface ablation. Use of MMC during the
laser custom CXL was associated with better outcomes, but in separate trials that could not
be directly compared. This study will use OCT measurements to evaluate the magnitudes of
direct and indirect laser actions after the procedure.
together. Another variation in technique involves the use of mitomycin-C (MMC), which is
effective in reducing corneal haze after the laser surface ablation. Use of MMC during the
laser custom CXL was associated with better outcomes, but in separate trials that could not
be directly compared. This study will use OCT measurements to evaluate the magnitudes of
direct and indirect laser actions after the procedure.
Inclusion Criteria:
- Diagnosis of keratoconus
- Minimum corneal thickness of 410 microns
Exclusion Criteria:
- Inability to maintain fixation for OCT imaging
- Inability to commit to required study visits
- Inability to give informed consent
- Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may
limit the visual outcome after surgery
- Mature cataracts if found to limit visual potential to worse than 20/40
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Phone: 503-494-4351
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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