Study In Healthy Subjects To Evaluate The Changes In The Protein sAPP-Alpha In Cerebrospinal Fluid Following A Single Oral Dose Of PF-04995274
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 12/5/2018 |
| Start Date: | September 2010 |
| End Date: | January 2011 |
A Phase 1 Investigator And Subject-Blind Study In Healthy Subjects To Evaluate The Pharmacodynamic Effects Of Single Doses Of PF-04995274 On Sapp-Alpha Concentrations In Cerebrospinal Fluid Using Serial Sampling Methodology
The primary purpose of the study is to evaluate the effect of PF-04995274 on cerebrospinal
fluid levels of soluble Amyloid precursor protein fragments and Amyloid beta fragments
following single oral dose in healthy volunteers. Safety and tolerability of PF-04995274
single dose administration in healthy volunteers will also be assessed as part of the
objectives.
fluid levels of soluble Amyloid precursor protein fragments and Amyloid beta fragments
following single oral dose in healthy volunteers. Safety and tolerability of PF-04995274
single dose administration in healthy volunteers will also be assessed as part of the
objectives.
The purpose of the study is to evaluate the effect of PF-04995274 on CSF levels of s-APP and
Abeta fragments following single oral dose in healthy volunteers
Abeta fragments following single oral dose in healthy volunteers
Inclusion Criteria:
- For all cohorts, healthy male and/or female subjects of nonchildbearing potential
between the ages of 18 and 55 years, inclusive. (Healthy is defined as no clinically
relevant abnormalities identified by a detailed medical history, full physical
examination, including blood pressure and heart rate measurement, 12 lead ECG and
clinical laboratory tests).
Exclusion Criteria:
- Evidence or history of clinically significant hematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
allergic disease (including drug allergies, but excluding untreated, asymptomatic,
seasonal allergies at time of dosing).
- Pregnant or nursing women; women of childbearing potential.
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