Developing Fast Pediatric Imaging

The purpose of the study is to develop new technologies for MRI systems. The new technologies
should improve MRI capabilities in terms of how sensitive, specific, and efficient they are.
The overall goal is to get better measurements of the brain tumor tissue(s).

In this research study, the investigators want to learn more about investigational software
and about techniques to process MR images. The testing of investigational software will allow
the investigators to improve the image quality. As part of the testing process, the
investigators will collect more MR images of the brain, and improve current image
reconstruction methods. This will allow a more precise analysis of MR images and potentially
better assessment of the brain tumor tissue volume.

Inclusion Criteria:

- Infants, children and adults who have been diagnosed with Low Grade Glioma

- Healthy volunteers - Children from age 0 to adults with no upper age limit or;

- Diagnosed with LGG and being treated at DFCI;

Exclusion Criteria:

- Electrical implants such as cardiac pacemakers or perfusion pumps;

- Ferromagnetic implants such as aneurysm clips, surgical clips, prosthesis, artificial
hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or
steel implants;

- Ferromagnetic objects such as jewelry or metal clips;

- Women of childbearing age who are seeking to become pregnant, who are breastfeeding,
or who suspect they may be pregnant;

- Pre-existing medical conditions including a likelihood of developing seizures or
claustrophobic reactions;

- Any greater than normal potential for cardiac arrest