OCT Angiography and NRAI in Dementia
| Status: | Recruiting |
|---|---|
| Conditions: | Alzheimer Disease, Cognitive Studies, Cognitive Studies, Neurology |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 55 - Any |
| Updated: | 12/5/2018 |
| Start Date: | September 14, 2018 |
| End Date: | December 2020 |
| Contact: | Denzil Romfh, OD |
| Email: | romfhd@ohsu.edu |
| Phone: | 503-494-4351 |
Using Optical Coherence Tomography and Noninvasive Retinal Amyloid Imaging to Capture Retinal Changes Associated With Dementia
The primary goals of this study are to use optical coherence tomography (OCT) angiography
(blood vessel mapping) to:
1. Detect retinal blood vessel and blood flow changes in participants with dementia.
2. Detect amyloid protein deposits in the retinas of participants with dementia.
(blood vessel mapping) to:
1. Detect retinal blood vessel and blood flow changes in participants with dementia.
2. Detect amyloid protein deposits in the retinas of participants with dementia.
Inclusion Criteria for dementia subjects:
- Physician-confirmed diagnosis of probable Alzheimer's disease
- Mild dementia, as defined by score of 20 or greater on the Mini-Mental State Exam, or
score of 15 or greater on the Montreal Cognitive Assessment, or Clinical Dementia
Rating Scale score of 1.
- Age older than 55 years.
- Able to comply with study procedures
- Corrected visual acuity at least 20/400 in either eye.
- Has a legally authorized representative who can sign study consent form and accompany
the participant to the OCT study visit.
Inclusion Criteria for dementia-free controls:
- Age older than 55 years
- Able to comply with study procedures
- Able to maintain stable fixation for OCT imaging
- Corrected visual acuity of at least 20/40 in either eye
- Dementia-free, as defined by score of 24 or greater on the Mini-Mental Status Exam, or
a score of 18 or greater on the Montreal Cognitive Assessment, or Clinical Dementia
Rating of <1.0.
Exclusion Criteria for both dementia and dementia-free subjects:
- Non-Alzheimer's disease related primary neurologic disease affecting the central
nervous system (i.e. multiple sclerosis, Parkinson's disease)
- Evidence on ophthalmological exam within the last year of other ocular diseases or
pathology that would confound the assessment of dementia (e.g. glaucoma, diabetic or
hypertensive retinal disease, amblyopia, etc.)
- Media opacity such as cataract, corneal scar, or vitreous opacity that could interfere
with retinal imaging.
- Previous intraocular surgery except for uncomplicated cataract extraction with
posterior chamber intraocular lens implantation
- Inability to maintain stable fixation for OCT imaging or provide informed consent
- Spherical equivalent refractive error greater than +3 or -7 diopters, or astigmatism
magnitude of greater than 2 diopters.
- Diabetes for more than 10 years or hemoglobin A1C level of > 10 within the 180 days
prior to OCT scanning.
- Uncontrolled hypertension. : SBP > 170 or DBP > 100
- Arrhythmia: irregular pulse, or heart rate not between 50 and 110 beats per minute
- Pregnancy or breast feeding.
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Phone: 503-494-4351
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
Click here to add this to my saved trials
