A Study Of PF-04171327 In The Treatment Of The Signs And Symptoms Of Rheumatoid Arthritis



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:12/6/2018
Start Date:October 2009
End Date:July 2010

Use our guide to learn which trials are right for you!

A Phase 2a, Randomized, Double-Blind, Active And Placebo-Controlled Study Of PF-04171327 In The Treatment Of The Signs And Symptoms Of Rheumatoid Arthritis

This study will investigate the safety and efficacy of an investigational drug, PF-04171327
on the signs and symptoms of rheumatoid arthritis in patients that require glucocorticoids
while on background methotrexate. This study will also look at the response of chemical and
biological markers in rheumatoid arthritis patients. Lastly, this study will measure the PK
(amount of drug in the blood) of methotrexate while patients may be taking PF-04171327.


Inclusion Criteria:

- Patients ≥ 18 years of age, diagnosed with rheumatoid arthritis for a minimum duration
of 3 months

- On stable dose of methotrexate for at least 6 weeks prior to screening

- Patient must have minimum disease activity level of ≥ 6 tender/painful joints, ≥ 6
swollen joints and CRP ≥ 0.7 mg/dL

- Not currently receiving steroid medication

Exclusion Criteria:

- Pregnant or nursing women

- Patients that have active infections, TB, HIV and/or Hepatitis B or C

- Patients that have a history of intolerance or significant adverse effects with the
use of glucocorticoids
We found this trial at
9
sites
Miami, Florida 33155
?
mi
from
Miami, FL
Click here to add this to my saved trials
Anniston, Alabama 36207
?
mi
from
Anniston, AL
Click here to add this to my saved trials
Bingham Farms, Michigan 48025
?
mi
from
Bingham Farms, MI
Click here to add this to my saved trials
Ceske Budejovice, 37001
?
mi
from
Ceske Budejovice,
Click here to add this to my saved trials
Daytona Beach, Florida 32114
?
mi
from
Daytona Beach, FL
Click here to add this to my saved trials
Duncansville, Pennsylvania 16635
?
mi
from
Duncansville, PA
Click here to add this to my saved trials
Ormond Beach, Florida 32174
?
mi
from
Ormond Beach, FL
Click here to add this to my saved trials
Springfield, Illinois 62704
?
mi
from
Springfield, IL
Click here to add this to my saved trials
Zephyrhills, Florida 33542
?
mi
from
Zephyrhills, FL
Click here to add this to my saved trials