Study To Establish The Effects Of PF-04457845 On Sleep In Healthy Volunteers
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies, Insomnia Sleep Studies |
| Therapuetic Areas: | Psychiatry / Psychology, Other |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 12/6/2018 |
| Start Date: | April 2010 |
| End Date: | June 2010 |
Double-Blind, Randomized, Multiple-Dose, Placebo-Controlled, 2-Way Crossover Study To Study Effects of PF-04457845 On Polysomnographic Endpoints In Healthy Volunteers
PF-04457845 has been shown to temporarily decrease the dream (REM) period of sleep in rats,
which suggests that PF-04457845 is active in rat's brains. This study is designed to see
whether this is also the case in man.
which suggests that PF-04457845 is active in rat's brains. This study is designed to see
whether this is also the case in man.
Inclusion Criteria:
- Healthy male subjects between the ages of 18 and 55 years
- Body Mass Index (BMI) between 17.5 and 30.5 kg/m2
- Total body weight >50 kg
Exclusion Criteria:
- History of any active sleep disorder
- History of any sleep or circadian rhythm sleep disorder including RLS, narcolepsy,
sleep apnea, phase advance or delay syndromes within the past 5 years
- Currently on or planning to be involved in night or rotating shift work or traveling
across more than four time zones in 14 days prior to screening
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