Image and Model Based Analysis of Lung Disease

Specifically, the investigators are interested in understanding the difference between the
normal aging process and the events that lead to emphysema. Additionally, the investigators
are interested in understanding the earliest signs (lung inflammation) of the disease process
leading to three lung diseases, which include emphysema, fibrosis and sarcoidosis; all of
which are described as "inflammatory lung diseases." The investigators will be using the data
from this study to help define the normal values for the measured properties as well as
deviation from normal values in smokers without defined lung disease and patients with
inflammatory lung disease. The investigators believe that the analysis and scanning
techniques being developed as part of this research will provide new and previously
unavailable information on normal and diseased lungs so that ultimately the investigators can
detect specific changes in the lungs due to a disease and measure any improvements in the
anatomy and/or function of the pulmonary system after a patient has undergone treatment. This
study involves research using X-Ray computed tomography (CT) scanner, which is similar to
previous CT scanners but operates much faster and provides finer image detail.

Inclusion Criteria:

- Non smokers, age 20-29, 40-49, 60-69, 80-89, cannot have smoked more than 20
cigarettes in their lifetime

- Smokers, age 20-29, 40-49, 60-69, 80-89, currently smoking a minimum of 1 pack (20
cigarettes) per day, normal smokers and mild to moderate Chronic Obstructive Pulmonary
Disease (COPD)

Exclusion Criteria:

- Allergies - no allergies to shellfish, eggs, iodine

- Medications - no medications (except for birth control) for in the 'normal' category

- No asthma - as self reported

- BMI (Body Mass Index) - must not exceed 32 or 100kg of weight

- No other radiology studies in the last 12 months

- No metal in lung field - no metal from larynx to stomach

- No known heart disease

- No known kidney disease or diabetes

- Must not be pregnant - subjects of childbearing potential with be given a urine
pregnancy test