A Study Of The Effect Of CE-224535 On Knee OA (Osteoarthritis) Pain



Status:Terminated
Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - 75
Updated:12/7/2018
Start Date:January 2007
End Date:August 2007

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A 2 Week, Randomized, Double Blind, Placebo And Positive Controlled, Parallel Group, Multicenter Study Of CE-224,535 In Subjects With Osteoarthritic Pain Of The Knee

CE-224535 is a new medication being developed as an analgesic and anti-inflammatory agent for
the treatment of the signs and symptoms of osteoarthritis (OA). The purpose of this study is
to evaluate the analgesic and anti inflammatory efficacy and safety of CE 224,535 versus
placebo and naproxen treatment in patients with OA knee pain.


Inclusion Criteria:

- Is a healthy adult 18 to 75 years of age, inclusive, in general good health and with
diagnosis of knee OA, as determined by the American College of Rheumatology (ACR)
clinical/radiographic classification criteria for OA of the knee.

- Women must be of non childbearing potential (amenorrhea for at least 1 year PLUS have
a serum follicle stimulating hormone (FSH) level >30 IU/L, bilateral oophorectomy or
hysterectomy), and have a confirmed negative serum pregnancy test at the screening
visit prior to randomization.

Exclusion Criteria:

- History of other diseases that may involve the study joint, including inflammatory
joint diseases, crystalline disease, endocrinopathies, metabolic diseases, infections,
neuropathic disorders, avascular necrosis, Paget's disease, or tumors.

- Women of childbearing potential, or who are pregnant or lactating.
We found this trial at
42
sites
Kansas City, Missouri 64111
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Anniston, Alabama 36207
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Anniston, AL
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Arlington, Virginia 22205
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Arlington, VA
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Ashland, Oregon 97520
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Ashland, OR
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Avon, Indiana 46123
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Avon, IN
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Baltimore, Maryland 21234
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Baltimore, MD
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Bayou La Batre, Alabama 36509
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Beavercreek, Ohio 45440
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Birmingham, Alabama 35209
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Birmingham, AL
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Bryan, Texas 77802
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Chicago, Illinois 60611
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Chicago, IL
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Cincinnati, Ohio 45242
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Cincinnati, OH
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Clearwater, Florida 33756
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Clearwater, FL
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Collierville, Tennessee 38017
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Collierville, TN
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Columbia, Missouri 65401
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Columbia, MO
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DeFuniak Springs, Florida 32435
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DeFuniak Springs, FL
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Denver, Colorado 80206
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Denver, CO
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Destin, Florida 32541
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Destin, FL
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Duncansville, Pennsylvania 16635
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Eugene, Oregon 97401
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Eugene, OR
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Flowood, Mississippi 39232
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Frederick, Maryland 21702
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Frederick, MD
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Gretna, Louisiana 70056
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Gretna, LA
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Gurnee, Illinois 60031
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Gurnee, IL
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Hot Springs, Arkansas 71913
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Indianapolis, Indiana 46234
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Indianapolis, IN
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Kenner, Louisiana 70065
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Kenner, LA
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Kettering, Ohio 45429
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Knoxville, Tennessee 37909
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Longview, Texas 75601
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Memphis, Tennessee 38103
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Metairie, Louisiana 70006
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Missoula, Montana 59808
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Missoula, MT
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Northridge, California 91328
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Northridge, CA
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Pensacola, Florida 32504
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Sacramento, California 95816
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San Antonio, Texas 78258
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San Antonio, TX
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Spokane, Washington 99204
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Spokane, WA
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Summerville, South Carolina 29485
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Tarzana, California 91356
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Tarzana, CA
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Trenton, New Jersey 08618
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Trenton, NJ
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Westminster, Colorado 80030
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Westminster, CO
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