A Study Of The Effect Of CE-224535 On Knee OA (Osteoarthritis) Pain
| Status: | Terminated |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 12/7/2018 |
| Start Date: | January 2007 |
| End Date: | August 2007 |
A 2 Week, Randomized, Double Blind, Placebo And Positive Controlled, Parallel Group, Multicenter Study Of CE-224,535 In Subjects With Osteoarthritic Pain Of The Knee
CE-224535 is a new medication being developed as an analgesic and anti-inflammatory agent for
the treatment of the signs and symptoms of osteoarthritis (OA). The purpose of this study is
to evaluate the analgesic and anti inflammatory efficacy and safety of CE 224,535 versus
placebo and naproxen treatment in patients with OA knee pain.
the treatment of the signs and symptoms of osteoarthritis (OA). The purpose of this study is
to evaluate the analgesic and anti inflammatory efficacy and safety of CE 224,535 versus
placebo and naproxen treatment in patients with OA knee pain.
Inclusion Criteria:
- Is a healthy adult 18 to 75 years of age, inclusive, in general good health and with
diagnosis of knee OA, as determined by the American College of Rheumatology (ACR)
clinical/radiographic classification criteria for OA of the knee.
- Women must be of non childbearing potential (amenorrhea for at least 1 year PLUS have
a serum follicle stimulating hormone (FSH) level >30 IU/L, bilateral oophorectomy or
hysterectomy), and have a confirmed negative serum pregnancy test at the screening
visit prior to randomization.
Exclusion Criteria:
- History of other diseases that may involve the study joint, including inflammatory
joint diseases, crystalline disease, endocrinopathies, metabolic diseases, infections,
neuropathic disorders, avascular necrosis, Paget's disease, or tumors.
- Women of childbearing potential, or who are pregnant or lactating.
We found this trial at
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