Efficacy and Safety of Celecoxib Versus Placebo in the Treatment of Patients With Osteoarthritis of the Knee Who Were Unresponsive to Naproxen and Ibuprofen
Status: | Completed |
---|---|
Conditions: | Arthritis, Osteoarthritis (OA) |
Therapuetic Areas: | Rheumatology |
Healthy: | No |
Age Range: | 40 - Any |
Updated: | 12/7/2018 |
Start Date: | December 2003 |
End Date: | September 2004 |
A Double-Blind, Placebo-Controlled Study of the Efficacy and Tolerability of Once Daily Celebrex® (Celecoxib) vs. Placebo in the Treatment of Subjects With Osteoarthritis of the Knee Non-Responsive to Naproxen and Ibuprofen
To compare the safety and efficacy of celecoxib versus placebo in the treatment of patients
with knee osteoarthritis who were unresponsive to treatment with prescription strength
naproxen and ibuprofen or who could not tolerate prescription strength naproxen and ibuprofen
with knee osteoarthritis who were unresponsive to treatment with prescription strength
naproxen and ibuprofen or who could not tolerate prescription strength naproxen and ibuprofen
Inclusion criteria:
- OA of the knee in flare state at baseline visit and functional capacity class of I-III
- Failed adequate trials of both naproxen and ibuprofen (prescription strength) within
the past 5 years due to lack of efficacy, tolerability or both; duration of
prescription strength ibuprofen and naproxen must have been a minimum of 2 weeks for
each drug at the respective recommended doses if failure was due to lack of efficacy,
and for any duration if failure was due to lack of tolerability
Exclusion criteria:
- Inflammatory arthritis or gout/pseudo-gout with acute flare within the past 2 years
(subjects with fibrositis or fibromyalgia will not be excluded)
- Received acetaminophen within 24 hours of baseline visit
- Use of mobility assisting device for less than six weeks prior to study screening or
use of a walker
- History of gastrointestinal (GI) perforation, obstruction, or bleeding
- Diagnosed or treated for GI ulcer within 60 days prior to first dose of study
medication
- Recieved corticosteroids or hyaluronic acid within certain timeframe before study
We found this trial at
30
sites
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