Vitamin D Deficiency and Atopic Dermatitis
| Status: | Terminated |
|---|---|
| Conditions: | Other Indications, Psoriasis, Gastrointestinal, Dermatology, Dermatology, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery, Gastroenterology, Other |
| Healthy: | No |
| Age Range: | 1 - 18 |
| Updated: | 12/7/2018 |
| Start Date: | November 2010 |
| End Date: | April 2013 |
Treatment Of Vitamin D Deficiency And Effect On Atopic Dermatitis Severity
Atopic dermatitis is a chronic skin disease characterized by a defective skin barrier,
inflammation, and increased propensity for skin infections. Vitamin D is a fat-soluble
vitamin that is primarily acquired through local production in the skin after ultraviolet
light exposure but can also be obtained through natural and supplemental dietary sources.
This randomized controlled trial will examine the effects of vitamin D repletion on atopic
dermatitis severity in patients with diagnosed deficiency. The investigators hypothesize that
pediatric patients with moderate or severe atopic dermatitis and vitamin D deficiency will
have improved cutaneous disease after treatment with high dose as compared to standard dose
vitamin D.
inflammation, and increased propensity for skin infections. Vitamin D is a fat-soluble
vitamin that is primarily acquired through local production in the skin after ultraviolet
light exposure but can also be obtained through natural and supplemental dietary sources.
This randomized controlled trial will examine the effects of vitamin D repletion on atopic
dermatitis severity in patients with diagnosed deficiency. The investigators hypothesize that
pediatric patients with moderate or severe atopic dermatitis and vitamin D deficiency will
have improved cutaneous disease after treatment with high dose as compared to standard dose
vitamin D.
Inclusion Criteria:
- Serum 25-hydroxyvitamin D level <20 ng/ml (<50 nmol/L)
- Diagnosed with atopic dermatitis by a CHW pediatric dermatologist
- Age 1-18 years old
- Primary residence in Milwaukee County
- Moderate and severe atopic dermatitis (Severity Scoring of Atopic Dermatitis [SCORAD]
score greater than 15)
- On clinic protocol treatment for their atopic dermatitis (desonide ointment twice
daily for the face and groin, triamcinolone 0.1% ointment twice daily for other areas)
We found this trial at
1
site
9000 W Wisconsin Ave #270
Milwaukee, Wisconsin 53226
Milwaukee, Wisconsin 53226
(414) 266-2000
Children's Hospital of Wisconsin Nothing matters more than our children. At Children's Hospital of Wisconsin,...
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