ROtational Thromboelastometry Activated Transfusion In Trauma Trial



Status:Recruiting
Conditions:Hospital
Therapuetic Areas:Other
Healthy:No
Age Range:14 - 100
Updated:12/7/2018
Start Date:May 2016
End Date:May 2020
Contact:Michael W. Cripps, M.D.
Email:michael.cripps@utshouthwestern.edu
Phone:214-648-2708

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Trial Summary
Trial Overview
Inclusion Criteria

Viscoelastic Guided Goal Directed Resuscitation of Severely Injured Patients

This is a randomized controlled trial to compare viscoelastic (VE) guided resuscitation to
fixed-ratio resuscitation in trauma patients with hemorrhagic shock on the utilization of
blood products, effects on coagulation and inflammatory mediators, and how these strategies
affect post resuscitation adverse events.

This is an open labeled study as the VE guided resuscitation will be based on the visible VE
results. Aim 1 will compare the number of blood products utilized in each resuscitation
strategy. Aim 2 will analyze the coagulation and inflammatory mediators in each resuscitation
strategy to determine if there is a difference in the mechanism of coagulopathy. Aim 3 will
determine if the different resuscitation strategies have an effect on post resuscitation
adverse events.

Inclusion Criteria:

1. Trauma patient

2. MTP Activation

3. Only patients ≥ 14 years old

4. Alive at 31 mins after arrival in ED

Exclusion Criteria:

1. Transfer from OSH

2. Received CPR for more than 5 mins

3. Burned

4. Pregnant or Prisoner

5. Known DNR

6. Jehovah's witness
We found this trial at
1
site
Parkland Memorial Hospital
5201 Harry Hines Blvd
Dallas, Texas 75235
(214) 590-8000
Principal Investigator: Michael W Cripps, MD
Phone: 214-648-2708
Parkland Memorial Hospital As our community's public health system, Parkland is the foundation for a...
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