A Study for Patients With Rheumatoid Arthritis on Methotrexate (MTX) With an Inadequate Response to TNFα Inhibitor Therapy

Inclusion Criteria:

- Have given written informed consent approval

- Women must not be at risk to become pregnant during study participation

- Diagnosis of Rheumatoid Arthritis

- Active Rheumatoid Arthritis

- Current, regular use of Methotrexate, at a stable dose

- Have been on at least 1 biologic tumor necrosis factor-alpha (TNFα) inhibitor therapy
and either failed or were intolerant to treatment

- Other criteria to be reviewed by study doctor

Exclusion Criteria:

- Use of excluded medications (reviewed by study doctor)

- Have medical findings which, in the opinion of the study doctor, put patient at an
unacceptable risk for participation in the study

- Have had recent or ongoing infection which, in the opinion of the study doctor put
patient at an unacceptable risk for participation

- Evidence of tuberculosis

- Have systemic inflammatory condition other than rheumatoid arthritis (RA), such as
juvenile RA, seronegative spondyloarthropathy, Crohn's disease, ulcerative colitis, or
psoriatic arthritis.

- Other criteria to be reviewed by study doctor