Interactions Between Drug Effects and Environments
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 12/8/2018 |
| Start Date: | December 2015 |
| End Date: | July 2018 |
Drug Contextual Conditioning With in Humans: Causes and Consequences
The purpose of the study is to determine how associations between drugs and the places where
they are experienced influence drug seeking, mood and acute drug responses.
they are experienced influence drug seeking, mood and acute drug responses.
Learned associations between drug effects and the people, places, and paraphernalia (cues)
linked with drug experiences are a major barrier to the treatment of drug addiction. These
links are remarkably persistent and can cause relapse to drug taking even after long periods
of abstinence. They are also key features in some of the foremost theories of addiction, yet
there is little clinical evidence of how these associations are formed and how they come to
profoundly control behavior. The long-term goal of this research is to understand how drug
cues become powerfully linked with drug experiences and their influence on mood and behavior.
In the proposed project, the investigators will use a de novo conditioning paradigm to
examine the influence of drug contexts on drug seeking, mood and acute drug responses. The
hypothesis is that drug-paired contexts gain motivational salience, induce approach, and
alter acute subjective responses to the drug.This knowledge will lead to novel treatment
strategies to counteract the effects of drug cues on mood and behavior, and also to prevent
relapse.
linked with drug experiences are a major barrier to the treatment of drug addiction. These
links are remarkably persistent and can cause relapse to drug taking even after long periods
of abstinence. They are also key features in some of the foremost theories of addiction, yet
there is little clinical evidence of how these associations are formed and how they come to
profoundly control behavior. The long-term goal of this research is to understand how drug
cues become powerfully linked with drug experiences and their influence on mood and behavior.
In the proposed project, the investigators will use a de novo conditioning paradigm to
examine the influence of drug contexts on drug seeking, mood and acute drug responses. The
hypothesis is that drug-paired contexts gain motivational salience, induce approach, and
alter acute subjective responses to the drug.This knowledge will lead to novel treatment
strategies to counteract the effects of drug cues on mood and behavior, and also to prevent
relapse.
Inclusion Criteria:
- past use of stimulants
- bmi 19-26
- hormonal birth control for women
Exclusion Criteria:
- current or recent (Past year) history of major axis I disorder
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