Cannabinoids for Pain Control During Medical Abortion

This is a randomized, double-blind, placebo-controlled trial comparing pain levels in women
undergoing medical abortion with one of two regimens: ibuprofen 800mg and a 5mg oral
dronabinol versus ibuprofen 800mg and placebo given at the time of misoprostol
administration. This study will include 62 women undergoing medical abortion. Women will be
randomized to dronabinol 5mg oral versus placebo. The primary outcome will be maximum
reported pain score within 24 hours of misoprostol administration.

Inclusion Criteria:

- Aged 21 years or older

- Seeking medical abortion

- In good health

- Pregnancy with intrauterine gestational sac up to 10 0/7 weeks, dated by ultrasound

- Able and willing to receive text messages via phone

- Literate in English

- Able and willing to give informed consent and agree to the study terms

- Have assistance at home; no motor vehicle use while taking study medications

Exclusion Criteria:

- Lack of access to cell phone and texting capabilities

- Early pregnancy failure

- Contraindications to the study medications: Dronabinol, Ibuprofen

- Contraindications to medical abortion with Mifepristone or Misoprostol

- History of methadone or heroin use

- Used alcohol in the past 24 hours

- Used marijuana >4 times per week

- Any opioid in the past 30 days

- Using additional pain medications