Study Comparing the PET Scan and MRI in Identifying Breast Malignancies in Women With Breast Abnormalities



Status:Completed
Conditions:Breast Cancer, Women's Studies
Therapuetic Areas:Oncology, Reproductive
Healthy:No
Age Range:18 - Any
Updated:7/11/2015
Start Date:January 2002
End Date:January 2014
Contact:Susan Hemingway
Email:hemingws@upstate.edu
Phone:315-464-5099

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Comparative Study of the Diagnostic Accuracy of Scintimammography (Fluorine 18-FDG PET Scintigraphic Imaging) and Magnetic Resonance Imaging in Identifying Malignant Breast Lesions, In Subjects With Breast Abnormalities

This is a study looking at advanced imaging such as PET/CT and MRI to see if they can
provide a more accurate assessment of the patient with dense breasts or difficult to
interpret mammograms. In addition, the ability to determine whether one or the other is more
accurate or whether both together would be appropriate in this clinical situation, may be
able to be measured.

The MRI studies are very sensitive for detection of breast histopathology but less specific
in differentiating between small low grade malignancies are more benign pathologies.
Multifocal pathology can be challenging in determining site(s) for biopsy.

PET scanning is specific in the measurement of metabolic glucose activity of various
histopathologies and is accurate in differentiating aggressive from benign pathology in
multifocal breast disease. A further drawback of PET is the lack of ability to observe
lesions less than 3-4mm in diameter.

In select cases the combination of MR and PET/CT is able to come to a more conclusive
diagnosis - specifically with bilateral or multifocal breast disease.


Inclusion Criteria:

- Woman who have breast volumes allowing utilization of MRI breast coil

- Patients who are considered, by radiologist reading the mammograms, to have non
interpretable or difficult to interpret x-ray studies. These patients may or may not
have palpable breast lumps and may and may not have suspicious areas on their x-ray
mammograms.

Exclusion Criteria:

- Women of child bearing potential not practicing a medically accepted method of birth
control

- Women who are pregnant or breast-feeding
We found this trial at
3
sites
Liverpool, New York 13088
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Syracuse, New York 13210
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Syracuse, New York 13202
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Syracuse, NY
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