Evaluation of the Benefits of FloraGLO™ Lutein on Skin Health

This is a randomized, double-blind, placebo-controlled, parallel twelve-week study of the
performance of an oral test product to evaluate the effects of twelve weeks of lutein
supplementation on skin health and appearance in healthy women. A seven-day washout period
will precede the evaluation period. The subjects in each cohort will use consume one softgel
of their assigned test product (treatment or placebo) daily in the morning with breakfast for
12 weeks. Changes in skin condition and appearance as well as blood chemistry will be
assessed using results from expert visual grading, instrumental assessments, skin and blood
assays and subjective questionnaire responses. Subjects will be recruited during the winter
season to account for seasonal variations of skin parameters.

Evaluation points will occur pre-application (Baseline; Week 0) and after 42 and 84 days of
use (D42, D84; Week 6, Week 12). Data will be collected on the following outcomes:

1. Skin Hydration 2. Skin texture/smoothness 2. Reduction of facial fine lines and wrinkles
3. Skin elasticity and firmness 4. Sagging skin, dry skin, skin tone, appearance from expert
clinical grading and subjective questionnaire responses.

6. Skin hydration 7. Skin collagen 8. Skin lipid content. 9. Skin Carotenoids

Inclusion Criteria:

1. Females in good health, and between the ages of 30 and 65 years old

2. Fitzpatrick Skin Type I-V

3. Mild to moderate loss of skin elasticity, wrinkles (global) and rough skin texture

4. Able to read, understand and sign an informed consent form

5. Willing and able to follow all study directions, attend study visits as scheduled and
willing to accept the restrictions of the study

6. Willing and able to maintain regular diet, exercise, hydration, and sleep patterns
throughout the study

Exclusion Criteria:

1. Participating in any other clinical study

2. Acute or chronic disease or medical condition

3. Unreliable or unlikely to be available for the duration of the study

4. Routine use of tanning bed(s)

5. History of abnormal response to sunshine

6. Current usage of medications with contraindication of enhancing sun exposure, or
medications for skin conditions.

7. History of allergic reactions, skin sensitization and/or known allergies to cosmetic
ingredients, toiletries, sunscreens, etc.

8. Immunocompromised subjects

9. Subject has a history of unconventional sleep patterns

10. Started Hormone Replacement Therapy within the last three months

11. Using oral contraception for less than three months

12. Known to be pregnant, lactating or planning to become pregnant within six months

13. Unable to communicate or cooperate with the Principal Investigator due to language
problems, poor mental development, or impaired cerebral function