Wearable Skin Sensors to Assess Nocturnal Scratch Behavior

Present an advanced flexible, and wearable sensor intimately coupled to the skin that can
measure the full spectrum of relevant physiological parameters associated with atopic
dermatitis including scratch count, scratch duration, scratch intensity, heart rate, heart
rate variability and respiratory rate.

Inclusion Criteria:

- Participants with mild to moderate atopic dermatitis ages 2 years or older. This will
be determined by clinical diagnosis of AD according to the Hanifin and Rajka criteria
with a baseline Investigators Global Assessment score of mild (2) or moderate (3)

- Systemic therapy use (e.g. oral corticosteroid, cyclosporine, methotrexate,
phototherapy) within 28 days of subject enrollment

- Topical corticosteroid use or topical calcineurin inhibitor use within 14 days of
subject enrollment

- Willingness and ability to set up an infrared video camera nightly

- Willing to apply topical crisaborole twice daily to affected atopic dermatitis areas
of the body

Exclusion Criteria:

- Active skin or systemic infection

- Inability to operate a smartphone or video camera

- Active atopic dermatitis on he dorsum of the hand or suprasternal notch