CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera
| Status: | Recruiting |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/13/2018 |
| Start Date: | November 5, 2018 |
| End Date: | October 2023 |
| Contact: | Robin Barnes, CRNP |
| Email: | rbarnes@som.umaryland.edu |
| Phone: | 410-706-6156 |
CVD 38000: Immunity, Microbiome, Epigenetics, and a Systems Biology Approach to the Study of Responses to Vaccination With Typhoid and/or Cholera
This is an open-label, non-randomized study. The purpose of this study is to better
understand how vaccines against typhoid fever and cholera affect the normal immune system and
bacteria in the intestine. Patients having standard-of-care endoscopies (colonoscopy and/or
esophagogastroduodenoscopy (EGD)) will be divided into 3 groups:
Group 1: Vivotif typhoid vaccination and/or Vaxchora cholera vaccination then endoscopy Group
2: Endoscopy, then Vivotif typhoid vaccination and/or Vaxchora cholera vaccination, then
follow-up endoscopy Group 3: Endoscopy without vaccination.
Both vaccines used in this study are licensed by the Food and Drug Administration (FDA) for
travelers to developing countries. Volunteers will be asked to donate tissue, blood, saliva
and stool samples for studying how the body responds to the typhoid and/or cholera vaccine.
understand how vaccines against typhoid fever and cholera affect the normal immune system and
bacteria in the intestine. Patients having standard-of-care endoscopies (colonoscopy and/or
esophagogastroduodenoscopy (EGD)) will be divided into 3 groups:
Group 1: Vivotif typhoid vaccination and/or Vaxchora cholera vaccination then endoscopy Group
2: Endoscopy, then Vivotif typhoid vaccination and/or Vaxchora cholera vaccination, then
follow-up endoscopy Group 3: Endoscopy without vaccination.
Both vaccines used in this study are licensed by the Food and Drug Administration (FDA) for
travelers to developing countries. Volunteers will be asked to donate tissue, blood, saliva
and stool samples for studying how the body responds to the typhoid and/or cholera vaccine.
Inclusion Criteria:
- 1. Age 18 years and older
- 2. Already scheduled to undergo an EGD or colonoscopy for screening, surveillance, or
a medically-indicated work-up at the University of Maryland Medical Center (main
campus or Midtown)
- 3. Able to provide written informed consent prior to initiation of any study
procedures
- 4. Healthy, as defined by considered fit to undergo outpatient elective
EGD/colonoscopy by the evaluating health care provider
Exclusion Criteria:
- 1. Pregnancy or nursing mother
- 2. Known coagulopathy or bleeding disorder preventing mucosal biopsy
- 3. History of Crohn's disease or ulcerative colitis
- 4. For Subjects undergoing lower endoscopy (colonoscopy) only: Surgical removal of the
ileocecal valve or any part of the small or large intestine (non-complicated
appendectomy will be considered eligible)
- 5. Allergic reaction to oral typhoid or cholera vaccine in the past
- 6. Immunosuppression from illness or treatment, including
1. immune-deficiency disorders such as Human Immunodeficiency Virus (HIV) or
Acquired Immunodeficiency Syndrome (AIDS)
2. leukemia, lymphoma, or cancers (localized non-melanoma skin cancers which are
deemed inactive should be considered eligible)
- 7. Receipt of any other vaccine two weeks prior to receipt of Ty21a or CVD 103-HgR
- 8. Positive urine pregnancy test (HCG) prior to colonoscopy or vaccination
We found this trial at
1
site
Baltimore, Maryland 21201
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