Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)
| Status: | Recruiting |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 12/22/2018 |
| Start Date: | November 29, 2018 |
| End Date: | April 30, 2023 |
| Contact: | Evan Kharasch, MD |
| Email: | katelynne.durrant@duke.edu |
| Phone: | 919-613-1154 |
The overall goal of this research is to improve perioperative pain treatment, decrease
post-operative opioid consumption, diminish opioid related side effects, and reduce postop
opioid prescribing (and hence opportunity for diversion, abuse, addiction, and fatal
overdose).
post-operative opioid consumption, diminish opioid related side effects, and reduce postop
opioid prescribing (and hence opportunity for diversion, abuse, addiction, and fatal
overdose).
This protocol will test the innovative, paradigm-shifting hypothesis that anesthesia for
outpatient surgery with long-duration opioids (methadone), compared with conventional
short-duration opioids, achieves better analgesia, with similar or diminished side effects,
may reduce development of chronic postsurgical pain, improves recovery, and importantly,
decreases postoperative opioid consumption and could hence diminish take-home opioid
prescribing and shrink the population reservoir of unused opioids available for diversion and
misuse. Two cohorts will be studied, but analyzed separately. 1) Short-stay, anticipated
next-day discharge surgery (compare short-duration vs long-duration opioid), 2) Same-day
discharge surgery (compare short-duration vs long-duration opioid).
outpatient surgery with long-duration opioids (methadone), compared with conventional
short-duration opioids, achieves better analgesia, with similar or diminished side effects,
may reduce development of chronic postsurgical pain, improves recovery, and importantly,
decreases postoperative opioid consumption and could hence diminish take-home opioid
prescribing and shrink the population reservoir of unused opioids available for diversion and
misuse. Two cohorts will be studied, but analyzed separately. 1) Short-stay, anticipated
next-day discharge surgery (compare short-duration vs long-duration opioid), 2) Same-day
discharge surgery (compare short-duration vs long-duration opioid).
Inclusion Criteria
- Age 18-65 years Undergoing general anesthesia and moderately painful ambulatory
surgery with anticipated postop stay of < 24 hours
- Signed, written, informed consent
Exclusion Criteria
- History of liver or kidney disease.
- Females who are pregnant or nursing.
- Chronic opioid use (e.g. preoperative daily use of methadone, fentanyl transdermal
patches, or ≥ 3 oxycodone pills)
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