Evaluation of Ecallantide for Treatment of Angiotensin Converting Enzyme (ACE) Inhibitor Induced Angioedema



Status:Terminated
Conditions:Skin and Soft Tissue Infections
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:18 - Any
Updated:12/14/2018
Start Date:June 1, 2011
End Date:June 1, 2012

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Trial Summary
Trial Overview
Inclusion Criteria

Evaluation of Ecallantide for the Acute Treatment of Angiotensin Converting Enzyme Inhibitor Induced Angioedema

A double-blind, randomized, controlled trial comparing the safety and effectiveness of
conventional therapy with ecallantide to conventional therapy with placebo.


Inclusion Criteria:

- Males and females 18 years of age or older

- Must currently be on ACE inhibitor therapy and have received a dose within 36 hours

- Presenting with ACEIA of the head/neck region within 12 hours after onset

- All females must have a negative urine pregnancy test prior to administration of the
study drug. Those who have had a total hysterectomy, bilateral oophorectomy or are two
years post-menopausal do not require a pregnancy test.

Exclusion Criteria:

- Hypersensitivity to ecallantide

- Pregnancy or breast feeding

- Patients who have had angioedema and were not concurrently on an ACE inhibitor

- Patients exhibiting urticaria

- Patients who are intubated or who have a tracheostomy related to the current episode
of angioedema

- Opinion of the investigator that the patient would not be a good candidate

- Participation in another investigational study within 30 days prior to enrollment
We found this trial at
39
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University Medical Center Brackenridge
Austin, Texas 78701
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Baylor College of Medicine
1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
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Tampa General Hospital
1 Tampa General Cir
Tampa, Florida 33606
(813) 844-7000
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Georgia Health Sciences University
1459 Laney-Walker Blvd
Augusta, Georgia 30901
(706) 721-3052
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Kings County Hospital Center
Brooklyn, New York 11203
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St. Joseph Regional Health Center
Bryan, Texas 77802
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Medical University of South Carolina
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
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University of Virginia Health System
1215 Lee St
Charlottesville, Virginia 22903
(434) 924-0211
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University Consultants in Allergy and Immunology
Chicago, Illinois 60612
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Chicago, IL
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Mercy Hospital and Medical Center
Chicago, Illinois 60616
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MetroHealth System
Cleveland, Ohio 44109
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Arrowhead Regional Medical Center
Colton, California 92324
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University Hospital East
Columbus, Ohio 43205
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Ohio State University Medical Center
Columbus, Ohio 43210
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UT Southwestern Medical Center at Dallas
Dallas, Texas 75390
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Dekalb Medical
Decatur, Georgia
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Henry Ford Hospital
2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
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Emergency Medicine Residency Program
Fort Worth, Texas 76104
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301 University Blvd.
Galveston, Texas 77555
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East Carolina University
1001 E 5th St
Greenville, North Carolina 27858
(252) 328-6131
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University of Kansas Medical Center
3901 Rainbow Blvd
Kansas City, Kansas 66160
(913) 588-5000
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Nevada Acess to Research and Education Study
Las Vegas, Nevada 89106
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University of California, Los Angeles, School of Medicine
Los Angeles, California 90024
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Winthrop University Hospital
259 1st St
Mineola, New York 11501
(516) 663-0333
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Hennepin County Medical Center
Minneapolis, Minnesota 55414
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Er Med, Llc
Montgomery, Alabama 36106
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Ochsner Clinic Foundation
New Orleans, Louisiana 70121
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Christiana Hospital, Department of Emergency Medicine
Newark, Delaware 19718
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Sentara Norfolk General Hospital
600 Gresham Dr
Norfolk, Virginia 23507
(757) 388-3000
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Thomas Jefferson University
1020 Walnut St
Philadelphia, Pennsylvania 19107
(215) 955-6000
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Albert Einstein Medical Center
5501 Old York Road
Philadelphia, Pennsylvania 19141
215-456-7890
Albert Einstein Medical Center Einstein Healthcare Network is a private, not-for-profit organization with several major...
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Allegheny General Hospital
320 E North Ave
Pittsburgh, Pennsylvania 15212
(412) 359-3131
Allegheny General Hospital At Allegheny General Hospital, our physicians and healthcare staff have earned an...
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Beaumont Hospital, Royal Oak
Royal Oak, Michigan 48314
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
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University of California San Diego Mecial Center
San Diego, California 92103
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Staten Island University Hospital
475 Seaview Ave
Staten Island, New York 10305
(718) 226-9000
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Beaumont Hospital, Troy
44201 Dequindre Road
Troy, Michigan 48085
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MedStar Washington Hospital Center
110 Irving St NW
Washington, District of Columbia 20010
(202) 877-7000
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Wake Forest Baptist Health
Winston-Salem, North Carolina 27157
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