Exercise, Cognitive Function and Neuroplasticity in Healthy Adults

The primary aim of the study is to compare the effects of a moderate intensity aerobic
exercise intervention (delivered at 55-64% age-predicted maximal heart rate) with a high
intensity aerobic exercise intervention (delivered at 65%-90% age-predicted maximal heart
rate) on measures that probe cortical synaptic plasticity using transcranial magnetic
stimulation (TMS) in sedentary healthy adults.

Inclusion Criteria:

- Adult males and females aged 18-60 years old

- Primary language is English

- Sedentary (defined as not engaging in purposeful physical activity more than 2 times
over the last two months)

- Exercise clearance

Exclusion Criteria:

- Presence of cognitive, neurologic or orthopedic conditions that could affect
performance of the testing and training procedures

- History of migraines.

- History of fainting spells of unknown or undetermined etiology that might constitute
seizures

- History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or
family history of treatment resistant epilepsy

- Any current history of a psychiatric illness

- Any unstable medical condition

- No medication is an absolute exclusion from TMS. Medications will be reviewed by the
Principal Investigator and a decision about inclusion will be made based on the
following:

- The subject's past medical history, drug dose, history of recent medication
changes or duration of treatment, and combination with other CNS active drugs.

- The published TMS guidelines review medications to be considered with TMS (Rossi,
Hallett, Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009).

- Any metal in the brain, skull or elsewhere unless approved by the responsible MD

- Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication
infusion pump, cochlear implant, vagal nerve stimulator)

- Intracranial lesion

- Substance abuse or dependence within the past six months Subjects who, in the
Investigator's opinion, might not be suitable for the study