Assessing the Stability of Transcranial Magnetic Stimulation Plasticity Responses

The primary aim of this study is to assess the reliability of TMS plasticity measures
recorded one week apart, on healthy individuals. The secondary aim is assess TMS plasticity
measures on healthy individuals after an acute bout of aerobic exercise. Participants will
complete 3 visits. Visits 1 and 2 comprise TMS plasticity testing, and on visit 3,
participants will complete a short bout of aerobic exercise before undergoing TMS plasticity
testing.

Inclusion Criteria:

- Adult males and females aged 18-70 years old.

- Primary language is English

- Exercise clearance

Exclusion Criteria:

- Presence of cognitive, neurologic or orthopedic conditions that could affect
performance of the testing and training procedures

- History of migraines

- History of fainting spells of unknown or undetermined etiology that might constitute
seizures

- History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or
family history of treatment resistance epilepsy

- Any current history of psychiatric illness

- Any unstable medical condition

- No medication is an absolute exclusion from TMS. Medications will be reviewed by the
Principal Investigator and a decision about inclusion will be made based on the
following:

- The subject's past medical history, drug does, history of recent medication changes or
duration of treatment, and combination with other central nervous system active drugs.

- The published TMS guidelines review medications to considered with TMS (Rossi, Hallet,
Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009)

- Any metal in the brain, skull or elsewhere unless approved by the responsible MD

- Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication
infusion pump, cochlear implant, vagal nerve stimulator)

- Intracranial lesion

- Substance abuse or dependence within the past six months