A Center Based Study of Pivotal Response Treatment for Preschoolers With Autism

The purpose of this study is to examine the effectiveness of pivotal response training (PRT)
in an intensive center-based preschool environment to treat social communication deficits in
children with autism spectrum disorder (ASD). The study will compare Pivotal Response
Treatment (PRT) to a delayed treatment group (DTG). PRT is a naturalistic behavioral
intervention based on the principles of applied behavior analysis which has shown to be
effective in treating the core deficits in children with ASD. The study will compare the
combination of parent training with intensive center-based PRT (PRT-C) to a DTG and will
include 44 children ages 2 to 3.11 years with ASD and social communication deficits.

Inclusion Criteria:

- Diagnosis of autism spectrum disorder (ASD) based on Autism Diagnostic Interview
Revised (ADI-R), Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2),
Diagnostic and Statistical Manual, 5th edition (DSM-5), and expert clinical opinion

- Boys and girls between 2 years and 3 years and 11 months

- Ability to participate in the testing procedures to the extent that valid standard
scores can be obtained

- Stable treatment (e.g., applied behavior analysis (ABA), speech therapy, psychotropic
medication(s) or biomedical intervention(s) for at least 1 month prior to baseline
measurements with no anticipated changes during study participation

- Developmentally delayed with Mullen Scales of Early Learning composite score below 85
(1 Standard Deviation below the mean)

- Availability of at least one English-speaking parent who can consistently participate
in parent training and research measures.

Exclusion Criteria:

- Current or lifetime diagnosis of severe psychiatric disorder (e.g., bipolar disorder,
etc.)

- Presence of active medical problem (e.g., unstable seizure disorder or heart disease)

- Child primary language other than English

- Previous adequate trial of Pivotal Response Treatment

- More than 15 hours per week of in-home applied behavior analysis (ABA).