Brain, Appetite, Teens, and Exercise
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 14 - 17 |
| Updated: | 12/23/2018 |
| Start Date: | September 1, 2018 |
| End Date: | December 2019 |
| Contact: | Amy Papa, MS |
| Email: | aepapa@cmh.edu |
| Phone: | 816-234-9230 |
Brain, Activity, Teens, and Exercise (BATE)
The long-term goal is to develop effective, evidence-based lifestyle interventions to prevent
and treat childhood obesity and related co-morbidities. The short-term goal, and the purpose
of this application, is to quantify appetite and neural mechanisms of food reward in
overweight/obese (OW/OB) sedentary youth and to quantify changes following the implementation
of a physical activity intervention. The central hypothesis is that appetite becomes
dysregulated at low levels of physical activity via neural reward pathways, and appetite
control will improve following a long-term exercise intervention. The investigators consider
this project a pilot study designed to generate data to be used for future external funding
opportunities, demonstrate collaboration between researchers, and test the feasibility of the
protocols.
and treat childhood obesity and related co-morbidities. The short-term goal, and the purpose
of this application, is to quantify appetite and neural mechanisms of food reward in
overweight/obese (OW/OB) sedentary youth and to quantify changes following the implementation
of a physical activity intervention. The central hypothesis is that appetite becomes
dysregulated at low levels of physical activity via neural reward pathways, and appetite
control will improve following a long-term exercise intervention. The investigators consider
this project a pilot study designed to generate data to be used for future external funding
opportunities, demonstrate collaboration between researchers, and test the feasibility of the
protocols.
Specific Aim 1: To identify associations between neural, psychological, and hormonal appetite
control pathways using subjective and objective measures of appetite and neurocognitive
assessments of reward pre-intervention.
Hypothesis 1: There will be significant cross-modulation of appetite across neural (brain
activation), psychological (subjective hunger), and hormonal pathways (satiety biomarkers),
though the temporal relationship between each in response to feeding is unknown.
Specific Aim 2: To assess the effectiveness of a physical activity intervention on eating
behavior in adolescents; OW/OB inactive adolescents will be randomly assigned to a 3-month
exercise intervention (Exercise +Newsletter), or a control condition (Newsletter).
Hypothesis 2a: Those exposed to the exercise intervention will have greater improvements
(compared to control group) in appetite (subjective self-reported hunger and palatability
responses, and, objectively, satiety and appetite hormones glucose, insulin, ghrelin, and
leptin, and calories consumed during ad libitum meal).
Hypothesis 2B. Compared to pre-intervention, OB/OW youth in the exercise group will show
decreased reward activation in regions of the brain when making decisions about appetizing
foods compared to post-intervention when hungry and when fed. In self-control regions,
compared to pre-intervention, the investigators will observe increased activity in both
hungry and fed conditions.
At the end of the proposed study, it is the expectation that the investigators will have
collected important preliminary data regarding how long-term structured exercise acts upon
appetite and neural mechanisms related to food reward in adolescents. Findings are key not
only to interventions targeting OW/OB youth, but also to public policy and health
recommendations for the importance of physical activity in children.
control pathways using subjective and objective measures of appetite and neurocognitive
assessments of reward pre-intervention.
Hypothesis 1: There will be significant cross-modulation of appetite across neural (brain
activation), psychological (subjective hunger), and hormonal pathways (satiety biomarkers),
though the temporal relationship between each in response to feeding is unknown.
Specific Aim 2: To assess the effectiveness of a physical activity intervention on eating
behavior in adolescents; OW/OB inactive adolescents will be randomly assigned to a 3-month
exercise intervention (Exercise +Newsletter), or a control condition (Newsletter).
Hypothesis 2a: Those exposed to the exercise intervention will have greater improvements
(compared to control group) in appetite (subjective self-reported hunger and palatability
responses, and, objectively, satiety and appetite hormones glucose, insulin, ghrelin, and
leptin, and calories consumed during ad libitum meal).
Hypothesis 2B. Compared to pre-intervention, OB/OW youth in the exercise group will show
decreased reward activation in regions of the brain when making decisions about appetizing
foods compared to post-intervention when hungry and when fed. In self-control regions,
compared to pre-intervention, the investigators will observe increased activity in both
hungry and fed conditions.
At the end of the proposed study, it is the expectation that the investigators will have
collected important preliminary data regarding how long-term structured exercise acts upon
appetite and neural mechanisms related to food reward in adolescents. Findings are key not
only to interventions targeting OW/OB youth, but also to public policy and health
recommendations for the importance of physical activity in children.
Inclusion Criteria
- Overweight/obese (BMI ≥85th to <99th percentile for age and sex)
- Weight stable
- Ages 14-17
- No meds that may alter metabolism
- Sedentary (<20 min/day exercise)
- At risk for T2D, according to American Diabetes Association (ADA) criteria:
- family history of T2D in first- or second- degree relative
- Race/ethnicity (Native American, African American, Latino, Asian American,
Pacific Islander)
- Signs of insulin resistance
- Maternal history of diabetes for gestational diabetes during child's gestation
- Willing to participate in an exercise program
- Willing to provide permission/assent
Exclusion Criteria:
- BMI <85th percentile for age and sex
- Weight not stable
- Age <14 or >17
- On meds that may alter metabolism
- Active (>20 min/day exercise)
- Not at risk for T2D, according to American Diabetes Association (ADA) criteria (see
above)
- Not willing to participate in an exercise program
- Not willing to provide permission/assent
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